The nanopeptide hormone vasopressin is a new player in the modulation of renal Na+ -Cl- cotransporter activity

被引：4

作者：

Gamba, Gerardo ^{[1
,2
,3
]}

机构：

[1] Inst Nacl Cardiol Ignacio Chavez, Mol Physiol Unit, Mexico City, DF, Mexico

[2] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mol Physiol Unit, Mexico City, DF, Mexico

[3] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City 04510, DF, Mexico

来源：

KIDNEY INTERNATIONAL | 2010年 / 78卷 / 02期

关键词：

SHORT-TERM STIMULATION; MEMBRANE TRANSLOCATION; SPAK; PHOSPHORYLATION; KINASES; PROTEIN; NKCC2; OSR1;

D O I：

10.1038/ki.2010.147

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Vasopressin is a modulator of salt and water reabsorption, with known effects in the thick ascending limb and the collecting duct. Pedersen et al. present evidence that vasopressin administration increases the phosphorylation of the apical thiazide-sensitive Na+-Cl- cotransporter in the distal convoluted tubule. These effects appear to be independent of the renin-angiotensin system and to be mediated by the intracellular kinase SPAK. These observations expand the vasopressin-sensitive region of the nephron. Kidney International (2010) 78, 127-129. doi:10.1038/ki.2010.147

引用

收藏

页码：127 / 129

页数：4

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