Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells

被引：216

作者：

Park, BH

Vogelstein, B

Kinzler, KW

机构：

[1] Johns Hopkins Oncol Ctr, Baltimore, MD 21231 USA

[2] Howard Hughes Med Inst, Baltimore, MD 21231 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 05期

关键词：

D O I：

10.1073/pnas.051630998

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that have been implicated in a variety of biologic processes. The PPAR delta isotype was recently proposed as a downstream target of the adenomatous polyposis coli (APC)/beta catenin pathway in colorectal carcinogenesis. To evaluate its role in tumorigenesis, a PPAR delta null cell line was created by targeted homologous recombination. When inoculated as xenografts in nude mice, PPAR delta -/- cells exhibited a decreased ability to form tumors compared with PPAR delta +/- and wild-type controls. These data suggest that suppression of PPAR delta expression contributes to the growth-inhibitory effects of the APC tumor suppressor.

引用

页码：2598 / 2603

页数：6

共 28 条

[1] 14-3-3σ is required to prevent mitotic catastrophe after DNA damage
Chan, TA
Hermeking, H
Lengauer, C
Kinzler, KW
Vogelstein, B
[J]. NATURE, 1999, 401 (6753) : 616 - 620
[2] Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis
Chan, TA
Morin, PJ
Vogelstein, B
Kinzler, KW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (02) : 681 - 686
[3] Peroxisome proliferator-activated receptors: insight into multiple cellular functions
Escher, P
Wahli, W
[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2000, 448 (02) : 121 - 138
[4] Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
Forman, BM
Chen, J
Evans, RM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (09) : 4312 - 4317
[5] Prostacyclin-mediated activation of peroxisome proliferator-activated receptor δ in colorectal cancer
Gupta, RA
Tan, J
Krause, WF
Geraci, MW
Willson, TM
Dey, SK
DuBois, RN
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) : 13275 - 13280
[6] A simplified system for generating recombinant adenoviruses
He, TC
Zhou, SB
da Costa, LT
Yu, J
Kinzler, KW
Vogelstein, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) : 2509 - 2514
[7] Identification of c-MYC as a target of the APC pathway
He, TC
Sparks, AB
Rago, C
Hermeking, H
Zawel, L
da Costa, LT
Morin, PJ
Vogelstein, B
Kinzler, KW
[J]. SCIENCE, 1998, 281 (5382) : 1509 - 1512
[8] PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
He, TC
Chan, TA
Vogelstein, B
Kinzler, KW
[J]. CELL, 1999, 99 (03) : 335 - 345
[9] Roles of PPARs in health and disease
Kersten, S
Desvergne, B
Wahli, W
[J]. NATURE, 2000, 405 (6785) : 421 - 424
[10] Kobayashi M, 1996, BIOTECHNIQUES, V21, P398

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