Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors

被引：14

作者：

Boger, DL

Kochanny, MJ

Cai, H

Wyatt, D

Kitos, PA

Warren, MS

Ramcharan, J

Gooljarsingh, LT

Benkovic, SJ

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Univ Kansas, Dept Biochem, Lawrence, KS 66045 USA

[3] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 06期

关键词：

D O I：

10.1016/S0968-0896(98)00040-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：643 / 659

页数：17

共 28 条

[1] NEW SYNTHETIC ROUTE TO QUINAZOLINE ANALOGS OF FOLIC-ACID [J].

ACHARYA, SP ;

HYNES, JB .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1975, 12 (06) :1283-1286

[2] STRUCTURES OF APO AND COMPLEXED ESCHERICHIA-COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE [J].

ALMASSY, RJ ;

JANSON, CA ;

KAN, CC ;

HOSTOMSKA, Z .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) :6114-6118

[3] SYNTHESIS OF 5-SUBSTITUTED QUINAZOLINES AS POTENTIAL ANTIMALARIAL AGENTS [J].

ASHTON, WT ;

HYNES, JB .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (11) :1233-1237

[4] STRUCTURAL FEATURES OF 5,10-DIDEAZA-5,6,7,8-TETRAHYDROFOLATE THAT DETERMINE INHIBITION OF MAMMALIAN GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE [J].

BALDWIN, SW ;

TSE, A ;

GOSSETT, LS ;

TAYLOR, EC ;

ROSOWSKY, A ;

SHIH, C ;

MORAN, RG .

BIOCHEMISTRY, 1991, 30 (07) :1997-2006

[5]

BIGHAM EC, 1993, HETEROCYCLES, V35, P1289

[6] TOTAL SYNTHESIS OF (-)-PYRIMIDOBLAMIC ACID AND DEGLYCOBLEOMYCIN A2 [J].

BOGER, DL ;

MENEZES, RF ;

HONDA, T .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1993, 32 (02) :273-275

[7] Functionalized analogues of 5,8,10-trideazafolate: Development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase [J].

Boger, DL ;

Haynes, NE ;

Warren, MS ;

Ramcharan, J ;

Kitos, PA ;

Benkovic, SJ .

BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (09) :1839-1846

[8] Abenzyl 10-formyl-trideazafolic acid (Abenzyl 10-formyl-TDAF): An effective inhibitor of glycinamide ribonucleotide transformylase [J].

Boger, DL ;

Haynes, NE ;

Warren, MS ;

Ramcharan, J ;

Marolewski, AE ;

Kitos, PA ;

Benkovic, SJ .

BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (09) :1847-1852

[9] Multisubstrate analogue based on 5,8,10-trideazafolate [J].

Boger, DL ;

Haynes, NE ;

Warren, MS ;

Ramcharan, J ;

Kitos, PA ;

Benkovic, SJ .

BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (09) :1853-1857

[10] 10-formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): A potent inhibitor of glycinamide ribonucleotide transformylase [J].

Boger, DL ;

Haynes, NE ;

Kitos, PA ;

Warren, MS ;

Ramcharan, J ;

Marolewski, AE ;

Benkovic, SJ .

BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (09) :1817-1830

← 1 2 3 →