Chemotherapy and the tumor microenvironment: the contribution of circulating endothelial cells

被引：14

作者：

Bertolini, Francesco ^{[1
]}

机构：

[1] European Inst Oncol, Div Hematol Oncol, Dept Med, I-20141 Milan, Italy

来源：

CANCER AND METASTASIS REVIEWS | 2008年 / 27卷 / 01期

关键词：

angiogenesis; endothelial cells; endothelial progenitors;

D O I：

10.1007/s10555-007-9110-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anti-angiogenic drugs, alone or in combination with chemotherapeutics, are increasingly used by medical oncologists. In many cases, however, their mechanism of action and the tailoring of optimal dosage/schedule are still elusive. Circulating endothelial cell (CEC) and progenitor (CEP) number and viability are modulated in a large series of diseases including cancer, and look promising as surrogate biomarkers for the definition of the optimal biological dose of anti-angiogenic drugs and for patients' stratification. Along with CECs and CEPs, potential EC- and CEP-related surrogate molecular markers such as VE-Cadherin and CD133 are currently under preclinical and clinical investigation.

引用

页码：95 / 101

页数：7

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