Cortical plasticity: It's all the range!

被引：57

作者：

Martin, SJ ^{[1
]}

Morris, RGM ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Neurosci, Edinburgh EH8 9LE, Midlothian, Scotland

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0960-9822(01)00015-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

When rats learn a motor skill, synaptic potentials in the motor cortex are enhanced. A new study has revealed that this learning-induced enhancement limits further synaptic potentiation, but not synaptic depression. These findings support the view that activity-dependent synaptic plasticity is the brain's memory mechanism.

引用

页码：R57 / R59

页数：3

共 20 条

[1]

Cortical plasticity: From synapses to maps [J].

Buonomano, DV ;

Merzenich, MM .

ANNUAL REVIEW OF NEUROSCIENCE, 1998, 21 :149-186

[2]

LONG-TERM POTENTIATION OF HORIZONTAL CONNECTIONS PROVIDES A MECHANISM TO REORGANIZE CORTICAL MOTOR MAPS [J].

HESS, G ;

DONOGHUE, JP .

JOURNAL OF NEUROPHYSIOLOGY, 1994, 71 (06) :2543-2547

[3]

Long-term depression of horizontal connections in rat motor cortex [J].

Hess, G ;

Donoghue, JP .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1996, 8 (04) :658-665

[4]

Conditions for the induction of long-term potentiation in layer II/III horizontal connections of the rat motor cortex [J].

Hess, G ;

Aizenman, CD ;

Donoghue, JP .

JOURNAL OF NEUROPHYSIOLOGY, 1996, 75 (05) :1765-1778

[5]

RESHAPING THE CORTICAL MOTOR MAP BY UNMASKING LATENT INTRACORTICAL CONNECTIONS [J].

JACOBS, KM ;

DONOGHUE, JP .

SCIENCE, 1991, 251 (4996) :944-947

[6]

Functional reorganization of the rat motor cortex following motor skill learning [J].

Kleim, JA ;

Barbay, S ;

Nudo, RJ .

JOURNAL OF NEUROPHYSIOLOGY, 1998, 80 (06) :3321-3325

[7]

Margolis David J., 1999, Society for Neuroscience Abstracts, V25, P888

[8]

Synaptic plasticity and memory: An evaluation of the hypothesis [J].

Martin, SJ ;

Grimwood, PD ;

Morris, RGM .

ANNUAL REVIEW OF NEUROSCIENCE, 2000, 23 :649-711

[9]

Fear conditioning induces a lasting potentiation of synaptic currents in vitro [J].

McKernan, MG ;

ShinnickGallagher, P .

NATURE, 1997, 390 (6660) :607-611

[10]

SYNAPTIC POTENTIATION IN THE RAT DENTATE GYRUS DURING EXPLORATORY LEARNING [J].

MOSER, E ;

MOSER, MB ;

ANDERSEN, P .

NEUROREPORT, 1993, 5 (03) :317-320

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