Sesquiterpene lactones from Smyrnium olusatrum

被引：30

作者：

El-Gamal, AA ^{[1
]}

机构：

[1] Univ Mansoura, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

来源：

PHYTOCHEMISTRY | 2001年 / 57卷 / 08期

关键词：

Smyrnium olusatrum; apiaceae; sesquiterpenes; eudesmen-8; alpha; 12-olide; glechomanolides; cytotoxic activity;

D O I：

10.1016/S0031-9422(01)00211-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fruits of Smyrnium olusatrum afforded three sesquiterpene lactones, namely, 1 beta ,8 beta -dihydroxyeudesman-3,7(11)-dien-8 alpha ,12-olide, 1 beta ,8 beta -dihydroxyeudesman-4(15),7(11)-dien-8 alpha ,12-olide, and 1 beta ,10 alpha ,4 alpha ,5 beta -diepoxy-6 beta -hydroxyglechoman-8 alpha ,12-olide. Four related known sesquiterpenes were also isolated and characterized. The structure elucidation of the isolated compounds was based primarily on 1D and 2D NMR analyses. The in vitro cytotoxicity of the extract and isolated compounds against P-388 mouse lymphoma cells will be also discussed. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：1197 / 1200

页数：4

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