Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype

被引：45

作者：

Tsuji, Brian T. ^{[1
,2
,3
,4
]}

von Eiff, Christof ^{[5
]}

Kelchlin, Pamela A. ^{[1
,2
]}

Forrest, Alan ^{[1
,2
]}

Smith, Patrick F. ^{[1
,2
,3
,4
]}

机构：

[1] SUNY Buffalo, Sch Pharm & Pharmaceut Sci, Lab Antimicrobial Pharmacodynam, Buffalo, NY 14260 USA

[2] SUNY Buffalo, New York State Ctr Excellence Bioinformat & Life, Buffalo, NY 14260 USA

[3] Roswell Pk Canc Inst, Dept Pharm, Buffalo, NY 14260 USA

[4] Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14260 USA

[5] Univ Munster, Inst Med Microbiol, Munster, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 04期

关键词：

D O I：

10.1128/AAC.01254-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.

引用

页码：1533 / 1537

页数：5

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