Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis

被引：8

作者：

Kakeya, Hiroshi ^{[1
]}

Miyazaki, Yoshitsugu ^{[2
]}

Senda, Hisato ^{[3
]}

Kobayashi, Tsutomu ^{[1
]}

Seki, Masafumi ^{[1
]}

Izumikawa, Koichi ^{[1
]}

Yamamoto, Yoshihiro ^{[1
]}

Yanagihara, Kazunori ^{[1
]}

Tashiro, Takayoshi ^{[1
]}

Kohno, Shigeru ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Nagasaki 8528501, Japan

[2] Natl Inst Infect Dis, Dept Bioact Mol, Tokyo, Japan

[3] Kaken Pharmaceut Co Ltd, Kyoto, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 05期

关键词：

D O I：

10.1128/AAC.01370-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.

引用

页码：1871 / 1872

页数：2

共 8 条

[1]

Comparative pharmacokinetics of three preparations of the new antifungal SPK-843 [J].

Bruzzese, T ;

Galmozzi, MR ;

Ferrari, VM ;

Sala, P ;

Bonabello, A .

CHEMOTHERAPY, 2001, 47 (06) :387-395

[2]

Pharmacokinetics in rats of N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diascorbate (SPK-843) [J].

Bruzzese, T ;

Galmozzi, MR ;

Buffa, G ;

Sala, P ;

Bonabello, A .

CHEMOTHERAPY, 2001, 47 (02) :77-85

[3]

A 77-kilodalton protein of Cryptococcus neoformans, a member of the heat shock protein 70 family, is a major antigen detected in the sera of mice with pulmonary Cryptococcosis [J].

Kakeya, H ;

Udono, H ;

Ikuno, N ;

Yamamoto, Y ;

Mitsutake, K ;

Miyazaki, T ;

Tomono, K ;

Koga, H ;

Tashiro, T ;

Nakayama, E ;

Kohno, S .

INFECTION AND IMMUNITY, 1997, 65 (05) :1653-1658

[4]

In vitro activity of a new polyene SPK-843 against Candida spp, Cryptococcus neoformans and Aspergillus spp clinical isolates [J].

Kantarcioglu, AS ;

Yucel, A ;

Vidotto, V .

JOURNAL OF CHEMOTHERAPY, 2003, 15 (03) :296-298

[5]

Amphotericin B and fluconazole, a potent combination therapy for cryptococcal meningitis [J].

Larsen, RA ;

Bauer, M ;

Thomas, AM ;

Graybill, JR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (03) :985-991

[6]

Preliminary study on in vitro activity and cytotoxicity on cell cultures of a new polyene antifungal molecule (SPA-S-843) [J].

Pessina, A ;

Rossoni, L ;

Piccirillo, M ;

Sala, G ;

Neri, MG .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 1999, 47 (02) :179-184

[7]

In vitro activity of a new polyene, SPA-S-843, against yeasts [J].

Rimaroli, C ;

Bruzzese, T .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (11) :3012-3013

[8]

SENDA H, 2000, 40 INT C ANT AG CHEM, P1093

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