Genome streamlining in a cosmopolitan oceanic bacterium

被引:829
作者
Giovannoni, SJ [1 ]
Tripp, HJ
Givan, S
Podar, M
Vergin, KL
Baptista, D
Bibbs, L
Eads, J
Richardson, TH
Noordewier, M
Rappé, MS
Short, JM
Carrington, JC
Mathur, EJ
机构
[1] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA
[2] Oregon State Univ, Ctr Gene Res & Biotechnol, Corvallis, OR 97331 USA
[3] Diversa Corp, San Diego, CA 92121 USA
[4] Univ Hawaii, Sch Ocean & Earth Sci & Technol, Hawaii Inst Marine Biol, Kaneohe, HI 96744 USA
关键词
D O I
10.1126/science.1114057
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The SAR11 clade consists of very small, heterotrophic marine alpha-proteobacteria that are found throughout the oceans, where they account for about 25% of all microbial cells. Pelagibacter ubique, the first cultured member of this clade, has the smallest genome and encodes the smallest number of predicted open reading frames known for a free-living microorganism. In contrast to parasitic bacteria and archaea with small genomes, P. ubique has complete biosynthetic pathways for all 20 amino acids and all but a few cofactors. P. ubique has no pseudogenes, introns, transposons, extrachromosomat elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell.
引用
收藏
页码:1242 / 1245
页数:4
相关论文
共 29 条
[1]   The genome sequence of Rickettsia prowazekii and the origin of mitochondria [J].
Andersson, SGE ;
Zomorodipour, A ;
Andersson, JO ;
Sicheritz-Pontén, T ;
Alsmark, UCM ;
Podowski, RM ;
Näslund, AK ;
Eriksson, AS ;
Winkler, HH ;
Kurland, CG .
NATURE, 1998, 396 (6707) :133-140
[2]   Microbial control of oceanic carbon flux: The plot thickens [J].
Azam, F .
SCIENCE, 1998, 280 (5364) :694-696
[3]   Experimental and theoretical bases of specific affinity, a cytoarchitecture-based formulation of nutrient collection proposed to supercede the Michaels-Menten paradigm of microbial kinetics [J].
Button, DK ;
Robertson, B ;
Gustafson, E ;
Zhao, XM .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 70 (09) :5511-5521
[5]   ANNUAL FLUX OF DISSOLVED ORGANIC-CARBON FROM THE EUPHOTIC ZONE IN THE NORTHWESTERN SARGASSO SEA [J].
CARLSON, CA ;
DUCKLOW, HW ;
MICHAELS, AF .
NATURE, 1994, 371 (6496) :405-408
[6]   Pathway alignment: application to the comparative analysis of glycolytic enzymes [J].
Dandekar, T ;
Schuster, S ;
Snel, B ;
Huynen, M ;
Bork, P .
BIOCHEMICAL JOURNAL, 1999, 343 :115-124
[7]   Accelerated evolution associated with genome reduction in a free-living prokaryote [J].
Dufresne, A ;
Garczarek, L ;
Partensky, F .
GENOME BIOLOGY, 2005, 6 (02)
[8]   RegB/RegA, a highly conserved redox-responding global two-component regulatory system [J].
Elsen, S ;
Swem, LR ;
Swem, DL ;
Bauer, CE .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2004, 68 (02) :263-+
[9]  
GIOVANNONI SJ, IN PRESS NATURE
[10]   Net community production of dissolved organic carbon [J].
Hansell, DA ;
Carlson, CA .
GLOBAL BIOGEOCHEMICAL CYCLES, 1998, 12 (03) :443-453