Alteration and reorganization of functional networks: a new perspective in brain injury study

被引：25

作者：

Castellanos, Nazareth P. ^{[1
]}

Bajo, Ricardo ^{[1
]}

Cuesta, Pablo ^{[1
]}

Antonio Villacorta-Atienza, Jose ^{[2
]}

Paul, Nuria ^{[3
]}

Garcia-Prieto, Juan ^{[1
]}

del-Pozo, Francisco ^{[1
]}

Maestu, Fernando ^{[1
,4
]}

机构：

[1] Univ Politecn Madrid, Ctr Biomed Technol, Lab Cognit & Computat Neurosci, E-28660 Madrid, Spain

[2] Univ Complutense Madrid, Sch Math, Dept Appl Math, Madrid, Spain

[3] Univ Complutense Madrid, Dept Basic Psychol Cognit Proc 1, Madrid, Spain

[4] Univ Complutense Madrid, Dept Basic Psychol Cognit Proc 2, Madrid, Spain

来源：

FRONTIERS IN HUMAN NEUROSCIENCE | 2011年 / 5卷

关键词：

brain injury; data classification; functional connectivity; neurophysiology; graph theory; GRAPH-THEORETICAL ANALYSIS; DIRECTED TRANSFER-FUNCTION; SMALL-WORLD NETWORKS; TIME-SERIES; GENERALIZED SYNCHRONIZATION; ALZHEIMERS-DISEASE; INFORMATION-FLOW; CAUSAL RELATIONS; CEREBRAL-CORTEX; MOTOR RECOVERY;

D O I：

10.3389/fnhum.2011.00090

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Plasticity is the mechanism underlying the brain's potential capability to compensate injury. Recently several studies have shown how functional connections among the brain areas are severely altered by brain injury and plasticity leading to are organization of the networks. This new approach studies the impact of brain injury by means of alteration of functional interactions. The concept of functional connectivity refers to the statistical interdependencies between physiological time series simultaneously recorded in various areas of the brain and it could be an essential tool for brain functional studies, being its deviation from healthy reference an indicator for damage. In this article, we review studies investigating functional connectivity changes after brain injury and subsequent recovery, providing an accessible introduction to common mathematical methods to infer functional connectivity, exploring their capabilities, future perspectives, and clinical uses in brain injury studies.

引用

页数：13

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