Limited ability of antigen-specific Th1 responses to inhibit Th2 cell development in vivo

被引：16

作者：

Yasumi, T ^{[1
]}

Katamura, K ^{[1
]}

Okafuji, I ^{[1
]}

Yoshioka, T ^{[1
]}

Meguro, T ^{[1
]}

Nishikomori, R ^{[1
]}

Kusunoki, T ^{[1
]}

Heike, T ^{[1
]}

Nakahata, T ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Pediat, Sakyo Ku, Kyoto 6068507, Japan

来源：

JOURNAL OF IMMUNOLOGY | 2005年 / 174卷 / 03期

关键词：

D O I：

10.4049/jimmunol.174.3.1325

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Th1 and Th2 cells mutually antagonize each other's differentiation. Consequently, allergen-specific Th1 cells are believed to be able to suppress the development of Th2 cells and to prevent the development of atopic disorders. To determine whether a pre-existing Ag-specific Th1 response can affect the development of Th2 cells in vivo. we used an immunization model of Ag-pulsed murine dendritic cell (DC) transfer to induce distinct Th responses. When transferred into naive mice. Ag-pulsed CD8alpha(+) DCs induced a Th1 response and the production of IgG2a, whereas CD8alpha(-) DCs primed a Th2 response and the production of IgE. In the presence of a pre-existing Ag-specific Th2 environment due to Ag-pulsed CD8a- DC transfer, CD8alpha(+) DCs failed to prime Th1 cells. In contrast, CD8alpha(-) DCs could prime a Th2 response in the presence of a pre-existing Ag-specific Th1 environment. Moreover, exogenous IL-4 abolished the Th1-inducing potential of CD8alpha(+) DCs; in Nitro. but the addition of IFN-gamma did not effectively inhibit the potential of CD8alpha(-) DCs to prime IL-4-producing cells. Thus, Th1 and Th2 cells differ in their potential to inhibit the development of the other. This suggests that the early induction of allergen-specific Th1 cells before allergy sensitization will not prevent the development of atopic disorders.

引用

页码：1325 / 1331

页数：7

共 53 条

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