Mass spectrometry in high-throughput proteomics: ready for the big time

被引：371

作者：

Nilsson, Tommy ^{[1
,2
]}

Mann, Matthias ^{[3
]}

Aebersold, Ruedi ^{[4
,5
]}

Yates, John R., III ^{[6
]}

Bairoch, Amos ^{[7
,8
]}

Bergeron, John J. M. ^{[1
,2
]}

机构：

[1] McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ, Canada

[2] McGill Univ, Dept Med, Montreal, PQ, Canada

[3] Max Planck Inst Biochem, Dept Prote & Signal Transduct, D-82152 Martinsried, Germany

[4] ETH, Swiss Fed Inst Technol, Inst Mol Syst Biol, Zurich, Switzerland

[5] Univ Zurich, Fac Sci, Zurich, Switzerland

[6] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA

[7] Univ Geneva, Geneva, Switzerland

[8] Swiss Inst Bioinformat, Geneva, Switzerland

来源：

NATURE METHODS | 2010年 / 7卷 / 09期

关键词：

PROTEIN BIOMARKERS; HUMAN GENOME; HUMAN-CELLS; IN-VIVO; QUANTIFICATION; REPOSITORY; IDENTIFICATIONS; REPRODUCIBILITY; ANNOTATION; DISCOVERY;

D O I：

10.1038/nmeth0910-681

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Mass spectrometry has evolved and matured to a level where it is able to assess the complexity of the human proteome. We discuss some of the expected challenges ahead and promising strategies for success.

引用

页码：681 / 685

页数：5

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