Multiple pathways for sorting mitochondrial precursor proteins

被引：245

作者：

Bolender, Natalia ^{[1
,2
]}

Sickmann, Albert ^{[3
]}

Wagner, Richard ^{[4
]}

Meisinger, Chris ^{[1
]}

Pfanner, Nikolaus ^{[1
]}

机构：

[1] Univ Freiburg, Inst Biochem & Molbiol, Zentrum Biochem & Mol Zellforschung, D-79104 Freiburg, Germany

[2] Univ Freiburg, Fak Biol, D-79104 Freiburg, Germany

[3] Univ Wurzburg, Rudolf Virchow Ctr, DFG Res Ctr Expt Biomed, D-97078 Wurzburg, Germany

[4] Univ Osnabruck, Osnabruck, Germany

来源：

EMBO REPORTS | 2008年 / 9卷 / 01期

基金：

美国国家航空航天局;

关键词：

MIA; PAM; SAM; TIM; TOM;

D O I：

10.1038/sj.embor.7401126

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria import hundreds of different precursor proteins from the cytosol. More than 50% of mitochondrial proteins do not use the classical import pathway that is guided by amino-terminal pre-sequences, but instead contain different types of internal targeting signals. Recent studies have revealed an unexpected complexity of the mitochondrial protein import machinery and have led to the discovery of new transport pathways. Here, we review the versatility of mitochondrial protein import and its connection to mitochondrial morphology, redox regulation and energetics.

引用

页码：42 / 49

页数：8

共 51 条

[1] Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20 [J].

Abe, Y ;

Shodai, T ;

Muto, T ;

Mihara, K ;

Torii, H ;

Nishikawa, S ;

Endo, T ;

Kohda, D .

CELL, 2000, 100 (05) :551-560

[2] The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes [J].

Albrecht, Reinhard ;

Rehling, Peter ;

Chacinska, Agnieszka ;

Brix, Jan ;

Cadamuro, Sergio A. ;

Volkmer, Rudolf ;

Guiard, Bernard ;

Pfanner, Nikolaus ;

Zeth, Kornelius .

EMBO REPORTS, 2006, 7 (12) :1233-1238

[3] Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c [J].

Allen, S ;

Balabanidou, V ;

Sideris, DP ;

Lisowsky, T ;

Tokatlidis, K .

JOURNAL OF MOLECULAR BIOLOGY, 2005, 353 (05) :937-944

[4] Preprotein translocase of the outer mitochondrial membrane: Reconstituted Tom40 forms a characteristic TOM pore [J].

Becker, L ;

Bannwarth, M ;

Meisinger, C ;

Hill, K ;

Model, K ;

Krimmer, T ;

Casadio, R ;

Truscott, KN ;

Schulz, GE ;

Pfanner, N ;

Wagner, R .

JOURNAL OF MOLECULAR BIOLOGY, 2005, 353 (05) :1011-1020

[5] Mitochondrial presequence translocase: Switching between TOM tethering and motor recruitment involves Tim21 and Tim17 [J].

Chacinska, A ;

Lind, M ;

Frazier, AE ;

Dudek, J ;

Meisinger, C ;

Geissler, A ;

Sickmann, A ;

Meyer, HE ;

Truscott, KN ;

Guiard, B ;

Pfanner, N ;

Rehling, P .

CELL, 2005, 120 (06) :817-829

[6] Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins [J].

Chacinska, A ;

Pfannschmidt, S ;

Wiedemann, N ;

Kozjak, V ;

Szklarz, LKS ;

Schulze-Specking, A ;

Truscott, KN ;

Guiard, B ;

Meisinger, C ;

Pfanner, N .

EMBO JOURNAL, 2004, 23 (19) :3735-3746

[7] The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway [J].

Curran, SP ;

Leuenberger, D ;

Leverich, EP ;

Hwang, DK ;

Beverly, KN ;

Koehler, CM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (42) :43744-43751

[8] The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier [J].

Curran, SP ;

Leuenberger, D ;

Oppliger, W ;

Koehler, CM .

EMBO JOURNAL, 2002, 21 (05) :942-953

[9] Role of Pam16's degenerate J domain in protein import across the mitochondrial inner membrane [J].

D'Silva, PR ;

Schilke, B ;

Walter, W ;

Craig, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (35) :12419-12424

[10] The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import [J].

Davis, Alison J. ;

Alder, Nathan N. ;

Jensen, Robert E. ;

Johnson, Arthur E. .

MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (02) :475-486

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