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Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

被引：1006
作者：
Brunet, A [1 ]
Datta, SR
Greenberg, ME
机构：
[1] Childrens Hosp, Dept Neurosci, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 03期
关键词：
D O I：
10.1016/S0959-4388(00)00211-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The PI3K-Akt signaling pathway plays a critical role in mediating survival signals in a wide range of neuronal cell types. The recent identification of a number of substrates for the serine/threonine kinase Akt suggests that it blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell death and survival. In addition, recent experiments suggest that Akt may also use metabolic pathways to regulate cell survival.
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页码：297 / 305
页数：9
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