A convenient method for the synthesis of norstatine derivatives from N-Fmoc or N-Boc amino acids

被引：4

作者：

Kourtal, S ^{[1
]}

Paris, J ^{[1
]}

机构：

[1] UNIV LYON 1, DEPT PHARM, LAB THERAPEUT CHEM, F-69373 LYON 08, FRANCE

来源：

LETTERS IN PEPTIDE SCIENCE | 1996年 / 3卷 / 02期

关键词：

beta-amino alpha-hydroxy acids; peptide mimetics; norstatines; amino aldehydes; propargylic alcohols;

D O I：

10.1007/BF00126736

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A new and convenient method for synthesizing norstatine derivatives has been developed. The key step is the preparation of propargylic alcohols from N-Fmoc or N-Boc amino aldehydes, followed by transformation to carboxylic acids after protection of the alcohols. The N-Boc-protected derivatives are coupled to a dipeptide sequence to afford peptide mimetics (norstatines).

引用

页码：73 / 78

页数：6

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