Cerebellar synaptic protein expression in schizophrenia

被引:97
作者
Eastwood, SL
Cotter, D
Harrison, PJ
机构
[1] Univ Oxford, Dept Psychiat, Oxford OX1 2JD, England
[2] Univ Oxford, Dept Clin Neurol, Oxford OX1 2JD, England
[3] Inst Psychiat, Dept Neuropathol, London SE5 8AF, England
基金
英国医学研究理事会;
关键词
cerebellum; human brain; mRNA; neuropathology; psychosis; synapse;
D O I
10.1016/S0306-4522(01)00141-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A cortico-subcortico-cerebellar neural circuit has been postulated to be important in the pathophysiology of schizophrenia. This study investigated whether there are synaptic changes in the cerebellum to accompany its putative involvement in the disorder. We measured the expression of three synaptic proteins (synaptophysin, complexin I and complexin II) in the cerebellar cortex of 16 subjects with schizophrenia and 16 controls using in situ hybridisation histochemistry and immunoautoradiography. Complexin I and II are expressed predominantly by inhibitory and excitatory neurones respectively. In schizophrenia, synaptophysin mRNA was decreased, as was complexin II and its mRNA. Complexin I mRNA and protein levels were unaltered. Expression of the mRNAs in the rat cerebellum was unaffected by 2 weeks administration of antipsychotic drugs (haloperidol, chlorpromazine, risperidone, olanzapine or clozapine). We conclude that there is synaptic pathology in the cerebellum in schizophrenia. By disrupting neural circuits, the alterations may contribute to the cerebellar dysfunction thought to occur in the disorder. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:219 / 229
页数:11
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