Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam

被引：48

作者：

Laphookhieo, S

Cheenpracha, S

Karalai, C

Chantrapromma, S

Rat-a-pa, Y

Ponglimanont, C ^{[1
]}

Chantrapromma, K

机构：

[1] Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90112, Songkhla, Thailand

[2] Walailak Univ, Inst Sci, Thasala 80160, Nakhon Si Thamm, Thailand

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 04期

关键词：

Cerbera odollam; Apocynaceae; cardenolide; cytotoxicity;

D O I：

10.1016/j.phytochem.2003.10.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cardenolide glycoside, 3beta-O-(2'-O-acetyl-1- thevetosyl)-15(14 --> 8)-abeo-5beta-(8R)-14-oxo-card-20(22)-enolide (2'-O-acetyl cerleaside A), was isolated from a methylene chloride extract of the seeds of Cerbera odollam, together with four known compounds: cerleaside A, 17alpha-neriifolin, 17beta-neriifolin and cerberin. Their structures were elucidated by spectroscopic methods. All compounds except cerleaside A exhibited cytotoxic activities against oral human epidermoid carcinoma (KB), human breast cancer cell (BC) and human small cell lung cancer (NCI-H187). (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：507 / 510

页数：4

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