Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processes

被引：197

作者：

Fischer, G ^{[1
]}

Aumüller, T ^{[1
]}

机构：

[1] Max Planck Res Unit Enzymol Prot Folding, D-06120 Halle An Der Saale, Germany

来源：

REVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOL 148 | 2004年 / 148卷

关键词：

D O I：

10.1007/s10254-003-0011-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In some cases, the slow rotational movement underlying peptide bond cis/trans isomerizations is found to control the biological activity of proteins. Peptide bond cis/trans isomerases as cyclophilins, Fk506-binding proteins, parvulins, and bacterial hsp70 generally assist in the interconversion of the polypeptide substrate cis/trans isomers, and rate acceleration is the dominating mechanism of action in cells. We present evidence disputing the hypothesis that some of the molecular properties of these proteins play an auxiliary role in enzyme function.

引用

页码：105 / 150

页数：46

共 248 条

[1] FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle
Aghdasi, B
Ye, KQ
Resnick, A
Huang, A
Ha, HC
Guo, X
Dawson, TM
Dawson, VL
Snyder, SH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) : 2425 - 2430
[2] Interaction with glycosaminoglycans is required for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T lymphocytes to extracellular matrix
Allain, F
Vanpouille, C
Carpentier, M
Slomianny, MC
Durieux, S
Spik, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (05) : 2714 - 2719
[3] Cyclophilins are induced by hypoxia and heat stress in myogenic cells
Andreeva, L
Motterlini, R
Green, CJ
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 237 (01) : 6 - 9
[4] Cyclophilin a peptidyl-prolyl isomerase activity promotes ZPR1 nuclear export
Ansari, H
Greco, G
Luban, J
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (20) : 6993 - 7003
[5] Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase
Arévalo-Rodríguez, M
Cardenas, ME
Wu, XY
Hanes, SD
Heitman, J
[J]. EMBO JOURNAL, 2000, 19 (14) : 3739 - 3749
[6] Chaperone function of FkpA, a heat shock prolyl isomerase, in the periplasm of Escherichia coli
Arié, JP
Sassoon, N
Betton, JM
[J]. MOLECULAR MICROBIOLOGY, 2001, 39 (01) : 199 - 210
[7] HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
Asea, A
Kraeft, SK
Kurt-Jones, EA
Stevenson, MA
Chen, LB
Finberg, RW
Koo, GC
Calderwood, SK
[J]. NATURE MEDICINE, 2000, 6 (04) : 435 - 442
[8] BACHINGER HP, 1987, J BIOL CHEM, V262, P17144
[9] COMPARISON OF RATE CONSTANTS DETERMINED BY TWO-DIMENSIONAL NMR-SPECTROSCOPY WITH RATE CONSTANTS DETERMINED BY OTHER NMR TECHNIQUES
BAINE, P
[J]. MAGNETIC RESONANCE IN CHEMISTRY, 1986, 24 (04) : 304 - 307
[10] A protein folding intermediate of ribonuclease T1 characterized at high resolution by 1D and 2D real-time NMR spectroscopy
Balbach, J
Steegborn, C
Schindler, T
Schmid, FX
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1999, 285 (02) : 829 - 842

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