Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients

被引：39

作者：

Díez, O

Osorio, A

Robledo, M

Barroso, A

Domènech, M

Cortés, J

Albertos, J

Sanz, J

Brunet, J

SanRomán, JM

Alonso, MC

Baiget, M

Benítez, J

机构：

[1] Hosp Santa Cruz & San Pablo, Serv Genet, E-08025 Barcelona, Spain

[2] Fdn Jimenez Diaz, Dept Genet, E-28040 Madrid, Spain

[3] Clin Ruber, Serv Cirugia, Madrid, Spain

[4] Hosp Santa Cruz & San Pablo, Med Oncol Serv, Barcelona, Spain

[5] Hosp Santa Cruz & San Pablo, Med Oncol Serv, E-08025 Barcelona, Spain

[6] Fdn Jimenez Diaz, Dept Cirugia Mama, E-28040 Madrid, Spain

来源：

BRITISH JOURNAL OF CANCER | 1999年 / 79卷 / 7-8期

关键词：

hereditary breast cancer; Jewish population; Sephardic;

D O I：

10.1038/sj.bjc.6690208

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We screened the 185delAG and 5382insC (BRCA1) and the 6174delT (BRCA2) mutation in 298 Spanish women with breast cancer. Two women (one with Sephardic ancestors) presented the 185delAG mutation and the same haplotype reported in Ashkenazim with this mutation. This suggests a common origin of the 185delAG in both Sephardic and Ashkenazi populations.

引用

页码：1302 / 1303

页数：2

共 11 条

[1] The 185delAG BRCA1 mutation originated before the dispersion of Jews in the Diaspora and is not limited to Ashkenazim [J].