Hedgehogs in the clinic

被引：3

作者：

McMahon, AP

Chuang, PT

机构：

来源：

NATURE MEDICINE | 1996年 / 2卷 / 12期

关键词：

D O I：

10.1038/nm1296-1308

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

收藏

页码：1308 / 1310

页数：3

相关论文

共 26 条

[1] The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal [J].

Alcedo, J ;

Ayzenzon, M ;

VonOhlen, T ;

Noll, M ;

Hooper, JE .

CELL, 1996, 86 (02) :221-232

[2] Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly [J].

Belloni, E ;

Muenke, M ;

Roessler, E ;

Traverso, G ;

SiegelBartelt, J ;

Frumkin, A ;

Mitchell, HF ;

DonisKeller, H ;

Helms, C ;

Hing, AV ;

Heng, HHQ ;

Koop, B ;

Martindale, D ;

Rommens, JM ;

Tsui, LC ;

Scherer, SW .

NATURE GENETICS, 1996, 14 (03) :353-356

[3] Sertoli cell signaling by Desert hedgehog regulates the male germline [J].

Bitgood, MJ ;

Shen, LY ;

McMahon, AP .

CURRENT BIOLOGY, 1996, 6 (03) :298-304

[4] HEDGEHOG AND BMP GENES ARE COEXPRESSED AT MANY DIVERSE SITES OF CELL-CELL INTERACTION IN THE MOUSE EMBRYO [J].

BITGOOD, MJ ;

MCMAHON, AP .

DEVELOPMENTAL BIOLOGY, 1995, 172 (01) :126-138

[5] Dual roles for patched in sequestering and transducing hedgehog [J].

Chen, Y ;

Struhl, G .

CELL, 1996, 87 (03) :553-563

[6] Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function [J].

Chiang, C ;

Ying, LTT ;

Lee, E ;

Young, KE ;

Corden, JL ;

Westphal, H ;

Beachy, PA .

NATURE, 1996, 383 (6599) :407-413

[7] PERSPECTIVES ON HOLOPROSENCEPHALY .1. EPIDEMIOLOGY, GENETICS, AND SYNDROMOLOGY [J].

COHEN, MM .

TERATOLOGY, 1989, 40 (03) :211-235

[8] SONIC-HEDGEHOG, A MEMBER OF A FAMILY OF PUTATIVE SIGNALING MOLECULES, IS IMPLICATED IN THE REGULATION OF CNS POLARITY [J].

ECHELARD, Y ;

EPSTEIN, DJ ;

STJACQUES, B ;

SHEN, L ;

MOHLER, J ;

MCMAHON, JA ;

MCMAHON, AP .

CELL, 1993, 75 (07) :1417-1430

[9] Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identify [J].

Ericson, J ;

Morton, S ;

Kawakami, A ;

Roelink, H ;

Jessell, TM .

CELL, 1996, 87 (04) :661-673

[10] Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome [J].

Hahn, H ;

Wicking, C ;

Zaphiropoulos, PG ;

Gailani, MR ;

Shanley, S ;

Chidambaram, A ;

Vorechovsky, I ;

Holmberg, E ;

Unden, AB ;

Gillies, S ;

Negus, K ;

Smyth, I ;

Pressman, C ;

Leffell, DJ ;

Gerrard, B ;

Goldstein, AM ;

Dean, M ;

Toftgard, R ;

ChenevixTrench, G ;

Wainwright, B ;

Bale, AE .

CELL, 1996, 85 (06) :841-851