Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats

被引：82

作者：

Webster, RP ^{[1
]}

Gawde, MD ^{[1
]}

Bhattacharya, RK ^{[1
]}

机构：

[1] BHABHA ATOM RES CTR,RADIAT BIOL & BIOCHEM DIV,BOMBAY 400085,MAHARASHTRA,INDIA

来源：

CANCER LETTERS | 1996年 / 109卷 / 1-2期

关键词：

aflatoxin B-1; N-nitrosodimethylamine; DNA damage; DNA repair enzymes; protective role; rutin;

D O I：

10.1016/S0304-3835(96)04443-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Administration of hepatocarcinogens aflatoxin B-1 and N-nitrosodimethylamine to rats caused single-strand breaks in nuclear DNA. Inclusion in the diet of rutin, a naturally occurring phenolic flavonoid glycoside, significantly reduced the appearance of such breaks. The protection against DNA damage was found to be reduction in the induction of repair enzymes polymerase, DNA polymerase beta and DNA ligase. Even associated with poly(ADP-ribose) a marginal dose of rutin was effective in this regard. Since DNA damage and inefficient repair are expected to initiate the process of carcinogenesis, modulation by rutin of these parameters emphasizes the protective role of this flavonoid against carcinogenesis induced by chemical carcinogens.

引用

页码：185 / 191

页数：7

共 52 条

[1] CHELATING AND FREE-RADICAL SCAVENGING MECHANISMS OF INHIBITORY-ACTION OF RUTIN AND QUERCETIN IN LIPID-PEROXIDATION [J].

AFANASEV, IB ;

DOROZHKO, AI ;

BRODSKII, AV ;

KOSTYUK, VA ;

POTAPOVITCH, AI .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (11) :1763-1769

[2] EFFECT OF PLANT FLAVONOIDS ON MICROSOME CATALYZED-REACTIONS OF AFLATOXIN-B1 LEADING TO ACTIVATION AND DNA ADDUCT FORMATION [J].

BHATTACHARYA, RK ;

FIROZI, PF .

CANCER LETTERS, 1988, 39 (01) :85-91

[3]

BHATTACHARYA RK, 1990, FLAVONOIDS BIOL MED, V3, P339

[4]

BHATTACHARYA RK, 1990, P 15 INT C U LOUIS P, V15, P179

[5] NUCLEI FROM RAT LIVER - ISOLATION METHOD THAT COMBINES PURITY WITH HIGH YIELD [J].

BLOBEL, G ;

POTTER, VR .

SCIENCE, 1966, 154 (3757) :1662-&

[6]

BOHR VA, 1987, CANCER RES, V47, P6426

[7]

BOULIKAS T, 1991, ANTICANCER RES, V11, P489

[8] DNA STRAND BREAKS, NAD METABOLISM, AND PROGRAMMED CELL-DEATH [J].

CARSON, DA ;

SETO, S ;

WASSON, DB ;

CARRERA, CJ .

EXPERIMENTAL CELL RESEARCH, 1986, 164 (02) :273-281

[9] EFFECTS OF SYNTHETIC AND NATURALLY-OCCURRING FLAVONOIDS ON BENZO[A]PYRENE METABOLISM BY HEPATIC MICROSOMES PREPARED FROM RATS TREATED WITH CYTOCHROME-P-450 INDUCERS [J].

CHAE, YH ;

MARCUS, CB ;

HO, DK ;

CASSADY, JM ;

BAIRD, WM .

CANCER LETTERS, 1991, 60 (01) :15-24

[10] EFFECT OF ELLAGIC ACID AND HYDROXYLATED FLAVONOIDS ON THE TUMORIGENICITY OF BENZO[A]PYRENE AND (+/-)-7-BETA,8-ALPHA-DIHYDROXY-9-ALPHA,10-ALPHA-EPOXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE ON MOUSE SKIN AND IN THE NEWBORN MOUSE [J].

CHANG, RL ;

HUANG, MT ;

WOOD, AW ;

WONG, CQ ;

NEWMARK, HL ;

YAGI, H ;

SAYER, JM ;

JERINA, DM ;

CONNEY, AH .

CARCINOGENESIS, 1985, 6 (08) :1127-1133

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