The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses

被引：468

作者：

Suh, WK

Gajewska, BU

Okada, H

Gronski, MA

Bertram, EM

Dawicki, W

Duncan, GS

Bukczynski, J

Plyte, S

Elia, A

Wakeham, A

Itie, A

Chung, S

Da Costa, J

Arya, S

Horan, T

Campbell, P

Gaida, K

Ohashi, PS

Watts, TH

Yoshinaga, SK

Bray, MR

Jordana, M

Mak, TW

机构：

[1] Univ Toronto, Ontario Canc Inst, Adv Med Discovery Inst, Toronto, ON M5G 2C1, Canada

[2] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2C1, Canada

[3] Univ Toronto, Dept Immunol, Toronto, ON M5G 2C1, Canada

[4] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8N 3Z5, Canada

[5] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

[6] Amgen Inc, Thousand Oaks, CA 91320 USA

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 09期

关键词：

D O I：

10.1038/ni967

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the in vivo function of the B7 family member B7-H3 (also known as B7RP-2) by gene targeting. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3-deficient mice developed more severe airway inflammation than did wild-type mice in conditions in which T helper cells differentiated toward type 1 (T(H)1) rather than type 2 (T H 2). B7-H3 expression was consistently enhanced by interferon-gamma but suppressed by interleukin 4 in dendritic cells. B7-H3-deficient mice developed experimental autoimmune encephalomyelitis several days earlier than their wild-type littermates, and accumulated higher concentrations of autoantibodies to DNA. Thus, B7-H3 is a negative regulator that preferentially affects T(H)1 responses.

引用

页码：899 / 906

页数：8

共 48 条

[1] Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection [J].