Common genetic risk factors for conduct disorder and alcohol dependence

被引:220
作者
Slutske, WS
Heath, AC
Dinwiddie, SH
Madden, PAF
Bucholz, KK
Dunne, MP
Statham, DJ
Martin, NG
机构
[1] Univ Missouri, Dept Psychol, Columbia, MO 65211 USA
[2] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63130 USA
[3] Queensland Inst Med Res, Epidemiol Unit, Brisbane, Qld 4006, Australia
关键词
D O I
10.1037/0021-843X.107.3.363
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
The association between retrospectively reported childhood conduct disorder (CD) and a history of alcohol dependence (PID) was examined in a sample of 2,682 male, female, and unlike-sex adult twin pairs. There was a strong association between CD and AD in both men (tetrachoric r = .34, odds ratio = 2.8) and women (tetrachoric r = .53, odds ratio = 9.9). Genetic factors accounted for most of the association between CD and AD liability in men and women, with the remainder of the association being due to nonshared individual-specific environmental factors. Genetic influences common to CD and AD accounted for 17% and 35% of the genetic variation in AD liability in men and women, respectively and accounted for 11% and 23% of the total Variation in AD liability in men and women, respectively. The results suggest that there are common genetic risk factors for CD and AD or that CD itself is an important genetically influenced risk factor for AD.
引用
收藏
页码:363 / 374
页数:12
相关论文
共 87 条
[1]  
Åmark C, 1951, ACTA PSYCH NEUROL SC, V70, P1
[2]  
[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th
[3]   PREDICTING SUBSTANCE USE IN EARLY ADOLESCENCE BASED ON PARENT AND TEACHER ASSESSMENT OF CHILDHOOD PSYCHIATRIC-DISORDER - RESULTS FROM THE ONTARIO CHILD HEALTH STUDY FOLLOW-UP [J].
BOYLE, MH ;
OFFORD, DR ;
RACINE, YA ;
FLEMING, JE ;
SZATMARI, P ;
LINKS, PS .
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, 1993, 34 (04) :535-544
[4]   Is a history of alcohol problems or of psychiatric disorder associated with attrition at 11-year follow-up? [J].
Bucholz, KK ;
Shayka, JJ ;
Marion, SL ;
Lewis, CE ;
Pribor, EF ;
Rubio, DM .
ANNALS OF EPIDEMIOLOGY, 1996, 6 (03) :228-234
[5]   A NEW, SEMISTRUCTURED PSYCHIATRIC INTERVIEW FOR USE IN GENETIC-LINKAGE STUDIES - A REPORT ON THE RELIABILITY OF THE SSAGA [J].
BUCHOLZ, KK ;
CADORET, R ;
CLONINGER, CR ;
DINWIDDIE, SH ;
HESSELBROCK, VM ;
NURNBERGER, JI ;
REICH, T ;
SCHMIDT, I ;
SCHUCKIT, MA .
JOURNAL OF STUDIES ON ALCOHOL, 1994, 55 (02) :149-158
[6]   EFFECTS OF ALCOHOL ON HUMAN-AGGRESSION - AN INTEGRATIVE RESEARCH REVIEW [J].
BUSHMAN, BJ ;
COOPER, HM .
PSYCHOLOGICAL BULLETIN, 1990, 107 (03) :341-354
[7]  
CADORET RJ, 1987, J STUD ALCOHOL, V48, P1
[8]   ALCOHOLISM AND ANTISOCIAL PERSONALITY - INTERRELATIONSHIPS, GENETIC AND ENVIRONMENTAL-FACTORS [J].
CADORET, RJ ;
OGORMAN, TW ;
TROUGHTON, E ;
HEYWOOD, E .
ARCHIVES OF GENERAL PSYCHIATRY, 1985, 42 (02) :161-167
[9]  
CADORET RJ, 1995, ARCH GEN PSYCHIAT, V52, P916
[10]   INFERENCE ABOUT GENETIC CORRELATIONS [J].
CAREY, G .
BEHAVIOR GENETICS, 1988, 18 (03) :329-338