Oxidized low-density lipoprotein induces the production of interleukin-8 by endothelial cells

被引:33
作者
Claise, C
Edeas, M
Chalas, J
Cockx, A
Abella, A
Capel, L
Lindenbaum, A
机构
[1] Department of Biochemistry, Hosp. Antoine Béclère, 92141 Clamart Cedex
关键词
atherosclerosis; oxidized low-density lipoprotein; EA.hy 926 endothelial cell; interleukin-8; RANTES; reactive oxygen species;
D O I
10.1016/S0014-5793(96)01255-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The concentration of interleukin-8 (IL-8) and RANTES was measured in culture supernatants of human EA.hy 926 endothelial cells incubated with oxidized low-density lipoproteins (LDL). Oxidized LDL induced a 3-fold increase in IL-8 production (p < 0.01), whereas RANTES was not detected, Native LDL did not stimulate IL-8 production, IL-8 production in oxidized-LDL-treated cells was mediated by reactive oxygen species, as it was partially inhibited by catalase and completely inhibited by glutathione peroxidase and N-acetylcysteine (p < 0.01).
引用
收藏
页码:223 / 227
页数:5
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