Evidence of infant blood pressure programming by maternal nutrition during pregnancy: A prospective randomized controlled intervention study

被引:37
作者
Aaltonen, Jonna [1 ,2 ]
Ojala, Tina [2 ,4 ,5 ]
Laitinen, Kirsi [1 ,3 ,4 ]
Piirainen, Tarja Johanna [1 ,3 ,4 ]
Poussa, Tuija Annika [6 ]
Isolauri, Erika [2 ,4 ]
机构
[1] Univ Turku, Dept Pediat, Funct Foods Forum, FIN-20520 Turku, Finland
[2] Univ Turku, Dept Pediat, Turku, Finland
[3] Univ Turku, Dept Biochem & Food Chem, Turku, Finland
[4] Turku Univ Cent Hosp, Dept Pediat, Turku, Finland
[5] Univ Helsinki, Childrens Hosp & Adolescents, Helsinki, Finland
[6] Stat Consult, Tampere, Finland
基金
芬兰科学院;
关键词
D O I
10.1016/j.jpeds.2007.05.048
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objectives To evaluate the impact of maternal nutrition during pregnancy on infant blood pressure. Study design Pregnant women (n = 256) were randomized into 3 groups: modified dietary intake according to current recommendations and probiotics (diet/probiotics), placebo (diet/placebo), laid a control/placebo group. In the infants born to these women, blood pressure was recorded at age 6 months using in automated oscillometric DINAMAP R. Results Despite significant differences in maternal dietary intakes between the study groups, the intervention focusing on maternal fat intake showed no direct impact on infants' blood pressure. Instead, a complex U-shaped interrelationship was Uncovered; the highest and lowest quartiles of intakes of specific nutrients, carbohydrate (P =.006 for systolic pressure and P =.015 for diastolic pressure), and monounsaturated fatty acids (P =.029 for diastolic pressure) compared with the middle quartiles resulted in higher blood pressure at age 6 months. The pattern between maternal carbohydrate intake during pregnancy and infants' blood pressure remained significant even after adjustment for breastfeeding and body length. A reverse U-shaped trend again was observed between maternal intake of fruits and infants' systolic blood pressure (P =.077). Conclusion With a view toward programming blood pressure to adulthood, our results suggest an opportunity for dietary counseling to promote child health.
引用
收藏
页码:79 / 84
页数:6
相关论文
共 42 条
[1]   Maternal energy stores and diet composition during pregnancy program adolescent blood pressure [J].
Adair, LS ;
Kuzawa, CW ;
Borja, J .
CIRCULATION, 2001, 104 (09) :1034-1039
[2]   Dietary approaches to prevent and treat hypertension - A scientific statement from the American Heart Association [J].
Appel, LJ ;
Brands, MW ;
Daniels, SR ;
Karanja, N ;
Elmer, PJ ;
Sacks, FM .
HYPERTENSION, 2006, 47 (02) :296-308
[3]   ESSENTIAL-HYPERTENSION PREDICTED BY TRACKING OF ELEVATED BLOOD-PRESSURE FROM CHILDHOOD TO ADULTHOOD - THE BOGALUSA HEART-STUDY [J].
BAO, WH ;
THREEFOOT, SA ;
SRINIVASAN, SR ;
BERENSON, GS .
AMERICAN JOURNAL OF HYPERTENSION, 1995, 8 (07) :657-665
[4]  
Barker DJP, 1992, FETAL INFANT ORIGINS
[5]   Metabolic syndrome in childhood: Association with birth weight, maternal obesity, and gestational diabetes mellitus [J].
Boney, CM ;
Verma, A ;
Tucker, R ;
Vohr, BR .
PEDIATRICS, 2005, 115 (03) :E290-E296
[6]   Diet in pregnancy and the offspring's blood pressure 40 years later [J].
Campbell, DM ;
Hall, MH ;
Barker, DJP ;
Cross, J ;
Shiell, AW ;
Godfrey, KM .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1996, 103 (03) :273-280
[7]  
Falkner B, 1996, PEDIATRICS, V98, P649
[8]   Tracking of systolic blood pressure during childhood: a 15-year follow-up population-based family study in eastern Finland [J].
Fuentes, RM ;
Notkola, IL ;
Shemeikka, S ;
Tuomilehto, J ;
Nissinen, A .
JOURNAL OF HYPERTENSION, 2002, 20 (02) :195-202
[9]   Maternal calcium intake and offspring blood pressure [J].
Gillman, MW ;
Rifas-Shiman, SL ;
Kleinman, KP ;
Rich-Edwards, JW ;
Lipshultz, SE .
CIRCULATION, 2004, 110 (14) :1990-1995
[10]   Gestational calcium supplementation and blood pressure in the offspring [J].
Hatton, DC ;
Harrison-Hohner, J ;
Coste, S ;
Reller, M ;
McCarron, D .
AMERICAN JOURNAL OF HYPERTENSION, 2003, 16 (10) :801-805