Recombination centres and the orchestration of V(D)J recombination

被引：419

作者：

Schatz, David G. ^{[1
,2
]}

Ji, Yanhong ^{[3
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

[3] Xi An Jiao Tong Univ, Sch Med, Dept Immunol & Microbiol, Xian 710049, Shaanxi, Peoples R China

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 04期

关键词：

HEAVY-CHAIN LOCUS; TCR-BETA LOCUS; IG-KAPPA LOCUS; ANTISENSE INTERGENIC TRANSCRIPTION; B-CELL DEVELOPMENT; GERMLINE TRANSCRIPTION; ALLELIC EXCLUSION; GENE SEGMENTS; IN-VIVO; IMMUNOGLOBULIN LOCI;

D O I：

10.1038/nri2941

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The initiation of V(D)J recombination by the recombination activating gene 1 (RAG1) and RAG2 proteins is carefully orchestrated to ensure that antigen receptor gene assembly occurs in the appropriate cell lineage and in the proper developmental order. Here we review recent advances in our understanding of how DNA binding and cleavage by the RAG proteins are regulated by the chromatin structure and architecture of antigen receptor genes. These advances suggest novel mechanisms for both the targeting and the mistargeting of V(D)J recombination, and have implications for how these events contribute to genome instability and lymphoid malignancy.

引用

页码：251 / 263

页数：13

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