Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid

被引：43

作者：

Capparelli, EV

Letendre, SL

Ellis, RJ

Patel, P

Holland, D

McCutchan, JA

机构：

[1] Univ Calif San Diego, Pediat Pharamcol Re Unit, San Diego, CA 92103 USA

[2] Univ Calif San Diego, HIV Neurobehav Res Ctr Grp, San Diego, CA 92103 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 06期

关键词：

D O I：

10.1128/AAC.49.6.2504-2506.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The distribution of abacavir into the cerebrospinal fluid (CSF) was assessed by use of a population pharmacokinetic analysis. Plasma and CSF abacavir concentrations in 54 subjects were determined. The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication.

引用

收藏

页码：2504 / 2506

页数：3

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