The pharmacology of LXR

被引：42

作者：

Michael, LF ^{[1
]}

Schkeryantz, JM ^{[1
]}

Burris, TP ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 08期

关键词：

nuclear receptor; steroid; HDL; LDL; transcription; heart disease; diabetes; inflammation;

D O I：

10.2174/1389557054553767

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors. Two LXRs (LXR alpha and LXR beta) were initially characterized as orphan members of this superfamily with disparate patterns of tissue expression. These two receptors later were recognized as sterol-responsive with the ability to directly bind several oxysterol metabolites. Many LXR target genes have been identified that implicate these receptors in a variety of physiological processes including cholesterol transport and metabolism, glucose metabolism, and inflammation. Synthetic LXR ligands have been designed with the potential to treat disorders such as atherosclerosis and diabetes. In this review, we describe the potential utility of LXR ligands in the treatment of disease.

引用

页码：729 / 740

页数：12

共 75 条

[1] A NOVEL ORPHAN RECEPTOR-SPECIFIC FOR A SUBSET OF THYROID HORMONE-RESPONSIVE ELEMENTS AND ITS INTERACTION WITH THE RETINOID/THYROID HORMONE-RECEPTOR SUBFAMILY [J].

APFEL, R ;

BENBROOK, D ;

LERNHARDT, E ;

ORTIZ, MA ;

SALBERT, G ;

PFAHL, M .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (10) :7025-7035

[2] Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters [J].

Berge, KE ;

Tian, H ;

Graf, GA ;

Yu, LQ ;

Grishin, NV ;

Schultz, J ;

Kwiterovich, P ;

Shan, B ;

Barnes, R ;

Hobbs, HH .

SCIENCE, 2000, 290 (5497) :1771-1775

[3] Novel peroxisome proliferator-activated receptor (PPAR) γ and PPARδ ligands produce distinct biological effects [J].

Berger, J ;

Leibowitz, MD ;

Doebber, TW ;

Elbrecht, A ;

Zhang, B ;

Zhou, GC ;

Biswas, C ;

Cullinan, CA ;

Hayes, NS ;

Li, Y ;

Tanen, M ;

Ventre, J ;

Wu, MS ;

Berger, GD ;

Mosley, R ;

Marquis, R ;

Santini, C ;

Sahoo, SP ;

Tolman, RL ;

Smith, RG ;

Moller, DE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (10) :6718-6725

[4] The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease [J].

Bodzioch, M ;

Orsó, E ;

Klucken, T ;

Langmann, T ;

Böttcher, L ;

Diederich, W ;

Drobnik, W ;

Barlage, S ;

Büchler, C ;

Porsch-Özcürümez, M ;

Kaminski, WE ;

Hahmann, HW ;

Oette, K ;

Rothe, G ;

Aslanidis, C ;

Lackner, KJ ;

Schmitz, G .

NATURE GENETICS, 1999, 22 (04) :347-351

[5] A natural product ligand of the oxysterol receptor, liver X receptor [J].

Bramlett, KS ;

Houck, KA ;

Borchert, KM ;

Dowless, MS ;

Kulanthaivel, P ;

Zhang, YY ;

Beyer, TP ;

Schmidt, R ;

Thomas, JS ;

Michael, LF ;

Barr, R ;

Montrose, C ;

Eacho, PI ;

Cao, GQ ;

Burris, TP .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 307 (01) :291-296

[6] Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency [J].

Brooks-Wilson, A ;

Marcil, M ;

Clee, SM ;

Zhang, LH ;

Roomp, K ;

van Dam, M ;

Yu, L ;

Brewer, C ;

Collins, JA ;

Molhuizen, HOF ;

Loubser, O ;

Ouelette, BFF ;

Fichter, K ;

Ashbourne-Excoffon, KJD ;

Sensen, CW ;

Scherer, S ;

Mott, S ;

Denis, M ;

Martindale, D ;

Frohlich, J ;

Morgan, K ;

Koop, B ;

Pimstone, S ;

Kastelein, JJP ;

Genest, J ;

Hayden, MR .

NATURE GENETICS, 1999, 22 (04) :336-345

[7] Oxysterols and atherosclerosis [J].

Brown, AJ ;

Jessup, W .

ATHEROSCLEROSIS, 1999, 142 (01) :1-28

[8] Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis [J].

Cao, GQ ;

Liang, Y ;

Broderick, CL ;

Oldham, BA ;

Beyer, TP ;

Schmidt, RJ ;

Zhang, YY ;

Stayrook, KR ;

Suen, C ;

Otto, KA ;

Miller, AR ;

Dai, JN ;

Foxworthy, P ;

Gao, H ;

Ryan, TP ;

Jiang, XC ;

Burris, TP ;

Eacho, PI ;

Etgen, GJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (02) :1131-1136

[9] Phospholipid transfer protein is regulated by liver X receptors in vivo [J].

Cao, GQ ;

Beyer, TP ;

Yang, XP ;

Schmidt, RJ ;

Zhang, YY ;

Bensch, WR ;

Kauffman, RF ;

Gao, H ;

Ryan, TP ;

Liang, Y ;

Eacho, PI ;

Jiang, XC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) :39561-39565

[10] Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages [J].

Castrillo, A ;

Joseph, SB ;

Marathe, C ;

Mangelsdorf, DJ ;

Tontonoz, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (12) :10443-10449

← 1 2 3 4 5 6 7 8 →