[1] Univ Sheffield, Royal Hallamshire Hosp, Div Clin Sci, Molec pharmacol & Pharmacogenet, Sheffield S10 2JF, S Yorkshire, England
[2] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England
[3] US FDA, Ctr Drug Evaluat & Res, OCBP, Rockville, MD 20852 USA