A polymeric form of fibronectin has antimetastatic effects against multiple tumor types

被引:113
作者
Pasqualini, R
Bourdoulous, S
Koivunen, E
Woods, VL
Ruoslahti, E
机构
[1] UNIV CALIF SAN DIEGO, SCH MED, LA JOLLA, CA 92093 USA
[2] UNIV HELSINKI, DEPT BIOSCI, DIV BIOCHEM, FIN-00014 HELSINKI, FINLAND
关键词
D O I
10.1038/nm1196-1197
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metastasis accounts for most deaths in cancer patients. Tumor cell adhesion to the extracellular matrix through integrins is thought to be a critical step in metastasis and a potential target for therapeutic intervention. We show here that treatment of human osteosarcoma, melanoma and carcinoma cells with a polymeric form of fibronectin (sFN), before inoculation into nude mice, prevented tumor formation. Intraperitoneally administered sFN significantly reduced lung colonization from intravenously injected tumor cells (experimental metastasis) and from subcutaneous tumors in nude mice (spontaneous metastasis). Treatment with sFN blocked cell spreading and migration in vitro suggesting a possible mechanism for the antimetastatic effect.
引用
收藏
页码:1197 / 1203
页数:7
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