Seeing is believing: The bicoid morphogen gradient matures

被引：136

作者：

Ephrussi, A

St Johnston, D

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

[2] Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QR, England

[3] Univ Cambridge, Dept Genet, Cambridge CB2 1QR, England

来源：

CELL | 2004年 / 116卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0092-8674(04)00037-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although Cell has a long history of publishing some of the most significant advances in developmental biology, the back to back papers by Driever and Nusslein-Volhard on the role of the Bicoid gradient in patterning the Drosophila embryo stand out as the first molecular demonstration of two of the longest standing concepts of the field, namely localized cytoplasmic determinants and morphogen gradients. Here we discuss the impact of this ground-breaking work and review recent results on bicoid mRNA localization and the dual role of Bicoid as a transcription and translation factor.

引用

页码：143 / 152

页数：10

共 104 条

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