Opiate addicts lack error-dependent activation of rostral anterior cingulate

被引:192
作者
Forman, SD
Dougherty, GG
Casey, BJ
Siegle, GJ
Braver, TS
Barch, DM
Stenger, VA
Wick-Hull, C
Pisarov, LA
Lorensen, E
机构
[1] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA
[2] Univ Pittsburgh, Dept Vet Affairs, Pittsburgh, PA USA
[3] Cornell Univ, Weill Med Coll, Sackler Inst Dev Psychobiol, New York, NY 10021 USA
[4] Washington Univ, Dept Psychol, St Louis, MO 63130 USA
关键词
substance-related disorders; heroin dependence; decision making; choice behavior; impulsivity; personality;
D O I
10.1016/j.biopsych.2003.09.011
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Healthy individuals performing response suppression tasks activate anterior cingulate cortex with occurrence of false alarm error responses to nontargets. Fundamental questions include whether this error-related activation provides a signal contributing to behavioral control and given generally poorer performance on such tasks by addicts, whether this signal is disrupted in addiction. Methods: We used rapid, event-related functional magnetic resonance imaging to study 13 individuals with opiate dependence and 26 healthy control individuals performing a Go/NoGo task. Results: Compared with controls, opiate addicts exhibited an attenuated anterior cingulate cortex error signal and significantly poorer task performance. In controls, the individual level of event-related anterior cingulate cortex activation accompanying false alarm error positively predicted task performance, particularly sensitivity in discriminating targets from nontargets. Conclusions: The attenuation of this error signal in anterior cingulate cortex may play a role in loss of control in addiction and other forms of impulsive behavior.
引用
收藏
页码:531 / 537
页数:7
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