Hydride-based silica stationary phases for HPLC: Fundamental properties and applications

被引：55

作者：

Pesek, JJ ^{[1
]}

Matyska, MT ^{[1
]}

机构：

[1] Calif State Univ, Chem Dept, San Jose, CA 95192 USA

来源：

JOURNAL OF SEPARATION SCIENCE | 2005年 / 28卷 / 15期

关键词：

aqueous normal phase; review; silica hydride; silanization/hydrosilation;

D O I：

10.1002/jssc.200500201

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Silica hydride is a recent development in chromatographic support materials for HPLC where hydride groups replace 95% of the silanols on the surface. This conversion changes many of the fundamental properties of the material as well as the bonded stationary phases that are the result of further chemical modification of the hydride surface. The general approach for fabricating the silica hydride and subsequent bonded phases is reviewed. Properties of the silica hydricle surface are compared to those of the standard material obtained in the preparation of most commercial HPLC stationary phases. Some unique chromatographic properties of hydride-based phases are described as well as some general application areas where these bonded materials may be used in preference to or have advantages not available from typical stationary phases.

引用

页码：1845 / 1854

页数：10

共 14 条

[1] Synthesis of chemically bonded squalene(ane) phases for microcolumn gas chromatographic separation of low-molecular-weight hydrocarbons in extraterrestrial atmospheres [J].