Immunopharmacology of modern antifungals

被引：100

作者：

Ben-Ami, R.

Lewis, R. E. ^{[2
]}

Kontoyiannis, D. P. ^{[1
,2
]}

机构：

[1] Univ Texas Houston, MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Unit 1460, Houston, TX 77030 USA

[2] Univ Houston, Coll Pharm, Houston, TX 77030 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2008年 / 47卷 / 02期

关键词：

D O I：

10.1086/589290

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In addition to their in vitro inhibitory and fungicidal effects, modern antifungal agents interact in vivo with host immune functions involved in defense against fungal pathogens. The nature of such interactions is diverse and depends on the drug, the immunological status of the host, and the fungal pathogen. Given the prominent role of the host's immune response in controlling invasive fungal infection, immunomodulation by antifungal drugs may prove to be clinically significant. Elucidation of the immunopharmacology of these drugs may aid in designing therapeutic regimens for specific clinical scenarios associated with defined immunological dysfunction.

引用

页码：226 / 235

页数：10

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