Cyclic ADP-ribose stimulates sarcoplasmic reticulum calcium release in porcine coronary artery smooth muscle

被引:80
作者
Kannan, MS
Fenton, AM
Prakash, YS
Sieck, GC
机构
[1] UNIV MINNESOTA, DEPT PEDIAT, ST PAUL, MN 55108 USA
[2] MAYO CLIN & MAYO FDN, DEPT ANESTHESIOL, ROCHESTER, MN 55905 USA
[3] MAYO CLIN & MAYO FDN, DEPT PHYSIOL & BIOPHYS, ROCHESTER, MN 55905 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1996年 / 270卷 / 02期
关键词
fluorescence imaging; ryanodine; caffeine; heparin; dissociated cells; beta-escin;
D O I
10.1152/ajpheart.1996.270.2.H801
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cyclic ADP-ribose (cADPR) was shown to induce calcium release from the endoplasmic reticulum via ryanodine-sensitive pathways. In smooth muscle, two pathways for calcium release from the sarcoplasmic reticulum (SR) have been previously demonstrated: D-myo-inositol 1,4,5-trisphosphate-gated and ryanodine-gated. However, evidence for cADPR as a regulator for SR Ca2+ release in smooth muscle is lacking. We used permeabilized porcine coronary artery smooth muscle cells to directly examine the stimulation of SR Ca2+ release by cADPR. The results provide direct evidence that cADPR stimulates SR Ca2+ release and that this response is not inhibited by heparin, by depletion of the caffeine-sensitive Ca2+ pool, or by blockade of ryanodine receptors. These results indicate a novel mechanism for Ca2+ release from the SR of vascular smooth muscle.
引用
收藏
页码:H801 / H806
页数:6
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