Reconciling the analysis of IBD and IBS in complex trait studies

被引：248

作者：

Powell, Joseph E. ^{[1
]}

Visscher, Peter M. ^{[1
]}

Goddard, Michael E. ^{[2
,3
]}

机构：

[1] Queensland Inst Med Res, Queensland Stat Genet Lab, Brisbane, Qld 4006, Australia

[2] Univ Melbourne, Dept Agr & Food Syst, Parkville, Vic 3010, Australia

[3] Dept Primary Ind, Bundoora, Vic 3083, Australia

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 11期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

INBREEDING COEFFICIENTS; LINKAGE DISEQUILIBRIUM; POPULATION; HERITABILITY; RELATEDNESS; DESCENT; HOMOZYGOSITY; PREDICTION; ACCURACY; IDENTITY;

D O I：

10.1038/nrg2865

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Identity by descent (IBD) is a fundamental concept in genetics and refers to alleles that are descended from a common ancestor in a base population. Identity by state (IBS) simply refers to alleles that are the same, irrespective of whether they are inherited from a recent ancestor. In modern applications, IBD relationships are estimated from genetic markers in individuals without any known relationship. This can lead to erroneous inference because a consistent base population is not used. We argue that the purpose of most IBD calculations is to predict IBS at unobserved loci. Recognizing this aim leads to better methods to estimating IBD with benefits in mapping genes, estimating genetic variance and predicting inbreeding depression.

引用

页码：800 / 805

页数：6

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