Ovarian cancer metastasis: Integrating insights from disparate model organisms

被引：438

作者：

Naora, H

Montell, DJ ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Mol Therapeut, Houston, TX 77030 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 05期

关键词：

D O I：

10.1038/nrc1611

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite considerable efforts to improve early detection, and advances in chemotherapy, metastasis remains a major challenge in the clinical management of ovarian cancer. Studies of new murine models are providing novel insights into the pathophysiology of ovarian cancer, but these models are not readily amenable to genetic screens. Genetic analysis of border-cell migration in the Drosophila melanogaster ovary provides clues that will improve our understanding of ovarian cancer metastasis at the molecular level, and also might lead to potential therapeutic targets.

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页码：355 / 366

页数：12

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