Effects of thalidomide on parameters involved in angiogenesis:: an in vitro study

被引：19

作者：

Gelati, M ^{[1
]}

Corsini, E ^{[1
]}

Frigerio, S ^{[1
]}

Pollo, B ^{[1
]}

Broggi, G ^{[1
]}

Croci, D ^{[1
]}

Silvani, A ^{[1
]}

Boiardi, A ^{[1
]}

Salmaggi, A ^{[1
]}

机构：

[1] Ist Nazl Neurol Carlo Besta, I-20133 Milan, Italy

来源：

JOURNAL OF NEURO-ONCOLOGY | 2003年 / 64卷 / 03期

关键词：

alpha v beta 3; angiogenesis; endothelial proliferation; IL-8; malignant glioma; MMP-2; thalidomide;

D O I：

10.1023/A:1025618022921

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In an attempt to elucidate the mechanism(s) of action of thalidomide, a reportedly antiangiogenic molecule recently tested in the treatment of relapsing malignant gliomas, we performed an in vitro study on the following parameters: (a) effect of thalidomide on proliferation of endothelial cells; (b) effect of thalidomide on expression of alphavbeta3 integrin on the surface of endothelial cells; (c) effect of thalidomide on the release by endothelial cells of MMP-2, IL-8 and TNF-alpha. The results show that thalidomide inhibits endotelial cell proliferation induced by bFGF and VEGF, more so if the cells are grown on vitronectin; moreover, treatment with thalidomide reduces the release of MMP-2 and IL-8 by endothelial cells, suggesting a further pathway for the antiangiogenic activity of drug. On the other hand, thalidomide does not modify expression of alphavbeta3 on endothelial cells.

引用

页码：193 / 201

页数：9

共 26 条

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