Citrullination: a small change for a protein with great consequences for rheumatoid arthritis

被引：174

作者：

van Venrooij, WJ ^{[1
]}

Pruijn, GJM ^{[1
]}

机构：

[1] Univ Nijmegen, Dept Biochem, NL-6500 HB Nijmegen, Netherlands

来源：

ARTHRITIS RESEARCH | 2000年 / 2卷 / 04期

关键词：

autoantibody; autoantigen; citrullination; deimination; rheumatoid arthritis;

D O I：

10.1186/ar95

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A new autoantibody activity, which is almost 100% specific for rheumatoid arthritis (RA), has been found. The essential part of the B-cell epitope is a modified form of arginine (ie citrulline). The conversion of protein-contained arginine to citrulline is an enzymatic process that is carried out by peptidylarginine deiminase (PAD), an enzyme that appears to be hormonally controlled. Because of its remarkable specificity, citrullination and related processes might open new possibilities for studying the aetiology of RA.

引用

页码：249 / 251

页数：3

共 21 条

[1] Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages [J].

Asaga, H ;

Yamada, M ;

Senshu, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 243 (03) :641-646

[2] AUTOANTIGENS TARGETED IN SYSTEMIC LUPUS-ERYTHEMATOSUS ARE CLUSTERED IN 2 POPULATIONS OF SURFACE-STRUCTURES ON APOPTOTIC KERATINOCYTES [J].

CASCIOLAROSEN, LA ;

ANHALT, G ;

ROSEN, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (04) :1317-1330

[3]

Girbal-Neuhauser E, 1999, J IMMUNOL, V162, P585

[4]

INAGAKI M, 1989, J BIOL CHEM, V264, P18119

[5] In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum [J].

Masson-Bessière, C ;

Sebbag, M ;

Durieux, JJ ;

Nogueira, L ;

Vincent, C ;

Girbal-Neuhauser, E ;

Durroux, R ;

Cantagrel, A ;

Serre, G .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2000, 119 (03) :544-552

[6]

MASSONBESSIERE C, 1999, REV RHUM, V66, P754

[7] Deimination of 70-kD nuclear protein during epidermal apoptotic events in vitro [J].

Mizoguchi, M ;

Manabe, M ;

Kawamura, Y ;

Kondo, Y ;

Ishidoh, K ;

Kominami, E ;

Watanabe, K ;

Asaga, H ;

Senshu, T ;

Ogawa, H .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1998, 46 (11) :1303-1309

[8] NEW SERUM FACTOR IN PATIENTS WITH RHEUMATOID ARTHRITIS - ANTIPERINUCLEAR FACTOR [J].

NIENHUIS, RL ;

MANDEMA, E .

ANNALS OF THE RHEUMATIC DISEASES, 1964, 23 (04) :302-+

[9] Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies [J].

Schellekens, GA ;

de Jong, BAW ;

van den Hoogen, FHJ ;

van de Putte, LBA ;

van Venrooij, WJ .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (01) :273-281

[10]

Schellekens GA, 2000, ARTHRITIS RHEUM-US, V43, P155, DOI 10.1002/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO

← 1 2 3 →