Increased risk of leukaemia in patients with juvenile chronic arthritis treated with chlorambucil

被引：26

作者：

Kauppi, MJ ^{[1
]}

Savolainen, HA ^{[1
]}

Anttila, VJ ^{[1
]}

Isomaki, HA ^{[1
]}

机构：

[1] UNIV HELSINKI HOSP, DEPT MED 3, HELSINKI, FINLAND

来源：

ACTA PAEDIATRICA | 1996年 / 85卷 / 02期

关键词：

D O I：

10.1111/j.1651-2227.1996.tb14004.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Two cases of acute leukaemia have developed in a group of 77 patients treated with chlorambucil (Chi) because of severe juvenile chronic arthritis. The total follow-up from the beginning of Chi treatment in these patients was 560 years, indicating a highly increased risk of leukaemia. Despite favourable results, especially in patients with secondary amyloidosis, Chi should only be used in selected cases.

引用

页码：248 / 250

页数：3

共 16 条

[1] CYTOTOXIC DRUG-TREATMENT OF REACTIVE AMYLOIDOSIS IN RHEUMATOID-ARTHRITIS WITH SPECIAL REFERENCE TO RENAL-INSUFFICIENCY [J].