Inflammasomes in pancreatic physiology and disease

被引：52

作者：

Hoque, Rafaz ^{[1
]}

Mehal, Wajahat Z. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Sect Digest Dis, New Haven, CT 06520 USA

[2] Dept Vet Affairs Connecticut Healthcare, Sect Digest Dis, West Haven, CT USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2015年 / 308卷 / 08期

基金：

美国国家卫生研究院;

关键词：

G protein-coupled receptor 109a; G protein-coupled receptor 81; mitochondrial oxidation; NACHT; LRR; and PYD domains-containing protein 3; TUMOR-NECROSIS-FACTOR; TOLL-LIKE RECEPTOR; HIGH-FAT-DIET; STERILE INFLAMMATORY RESPONSE; ACINAR-CELL NECROSIS; IL-1; RECEPTOR; REDUCES LIVER; KAPPA-B; ACTIVATION; ACID;

D O I：

10.1152/ajpgi.00388.2014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

In this review we summarize the role of inflammasomes in pancreatic physiology and disease with a focus on acute pancreatitis where much recent progress has been made. New findings have identified inducers of and cell specificity of inflammasome component expression in the pancreas, the contribution of inflammasome-regulated effectors to pancreatitis, and metabolic regulation of inflammasome activation, which are strong determinants of injury in pancreatitis. New areas of pancreatic biology will be highlighted in the context of our evolving understanding of gut microbiome-and injury-induced inflammasome priming, pyroptosis, and innate immune-mediated regulation of cell metabolism.

引用

收藏

页码：G643 / G651

页数：9

相关论文

共 101 条

[1]

Fas-mediated apoptosis in a rat acinar cell line is dependent on caspase-1 activity [J].

Aiba-Masago, S ;

Masago, R ;

Vela-Roch, N ;

Talal, N ;

Dang, H .

CELLULAR SIGNALLING, 2001, 13 (09) :617-624

[2]

Role of the gut in the course of severe acute pancreatitis [J].

Ammori, BJ .

PANCREAS, 2003, 26 (02) :122-129

[3]

Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration [J].

Bae, Jiyoung ;

Ricciardi, Carolyn J. ;

Esposito, Debora ;

Komarnytsky, Slavko ;

Hu, Pan ;

Curry, Benjamin J. ;

Brown, Patricia L. ;

Gao, Zhanguo ;

Biggerstaff, John P. ;

Chen, Jiangang ;

Zhao, Ling .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2014, 306 (10) :C918-C930

[4]

Dendritic Cells Promote Pancreatic Viability in Mice With Acute Pancreatitis [J].

Bedrosian, Andrea S. ;

Nguyen, Andrew H. ;

Hackman, Michael ;

Connolly, Michael K. ;

Malhotra, Ashim ;

Ibrahim, Junaid ;

Cieza-Rubio, Napoleon E. ;

Henning, Justin R. ;

Barilla, Rocky ;

Rehman, Adeel ;

Pachter, H. Leon ;

Medina-Zea, Marco V. ;

Cohen, Steven M. ;

Frey, Alan B. ;

Acehan, Devrim ;

Miller, George .

GASTROENTEROLOGY, 2011, 141 (05) :1915-U508

[5]

Metabolic basis of ethanol-induced hepatic and pancreatic injury in hepatic alcohol dehydrogenase deficient deer mice [J].

Bhopale, Kamlesh K. ;

Wu, Hai ;

Boor, Paul J. ;

Popov, Vsevolod L. ;

Ansari, G. A. S. ;

Kaphalia, Bhupendra S. .

ALCOHOL, 2006, 39 (03) :179-188

[6]

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies [J].

Brydges, Susannah D. ;

Broderick, Lori ;

McGeough, Matthew D. ;

Pena, Carla A. ;

Mueller, James L. ;

Hoffman, Hal M. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (11) :4695-4705

[7]

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia [J].

Cani, P. D. ;

Neyrinck, A. M. ;

Fava, F. ;

Knauf, C. ;

Burcelin, R. G. ;

Tuohy, K. M. ;

Gibson, G. R. ;

Delzenne, N. M. .

DIABETOLOGIA, 2007, 50 (11) :2374-2383

[8]

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events [J].

Cavassani, Karen A. ;

Ishii, Makoto ;

Wen, Haitao ;

Schaller, Matthew A. ;

Lincoln, Pamela M. ;

Lukacs, Nicholas W. ;

Hogaboam, Cory M. ;

Kunkel, Steven L. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (11) :2609-2621

[9]

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1 [J].

Cayrol, Corinne ;

Girard, Jean-Philippe .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (22) :9021-9026

[10]

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction [J].

Chalkiadaki, Angeliki ;

Guarente, Leonard .

CELL METABOLISM, 2012, 16 (02) :180-188

← 1 2 3 4 5 6 7 8 9 10 →