Intubating conditions and time course of rocuronium-induced neuromuscular block in children

被引:44
作者
FuchsBuder, T
Tassonyi, E
机构
[1] Dept. Anaesthiol., Pharmacol., S., Division of Anaesthesiology, Geneva University Hospital, CH-1211 Geneva 14, 24, rue Micheli-du-Crest
关键词
anaesthesia; paediatric; children; neuromuscular block; rocuronium; anaesthetic techniques induction; measurement techniques; electromyography;
D O I
10.1093/bja/77.3.335
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We have investigated the potential of rocuronium 0.6 mg kg(-1) (2 x ED(95)) and 0.9 mg kg(-1) (3 x ED(95)) for rapid sequence induction in 100 children, aged 3-7 yr. Intubating conditions with the two different doses of rocuronium were assessed in 70 children (n = 35 in each group) undergoing elective surgery. Intubation was carried out by mimicking rapid sequence induction, and intubation conditions were evaluated according to a standard score. Intubating conditions were good to excellent in all 70 patients investigated (2 x ED(95): excellent 29, good 6; 3 x ED(95): excellent 33, good 2). In another 30 children (n = 15 in each group), we examined the times of rocuronium-induced neuromuscular block using electromyography. Lag time and recovery index did not differ significantly between the two groups (lag time: 37 (SD 12) vs 33 (14) s; recovery index: 9 (3) vs 10 (4) min). Three times the ED(95) induced deeper neuromuscular block, 1 min after injection compared with 2 x ED(95) (twitch height: 42 (24) vs 25 (19)%, respectively; P < 0.05). The same was true for onset time (193 (47) vs 118 (23) s; P < 0.01), clinical duration (21 (4) vs 34 (11) min; P < 0.01) and duration to 75% recovery (30 (6) vs 44 (4) min; P < 0.01). By mimicking rapid sequence induction, both doses of rocuronium offered clinically acceptable (good or excellent) intubating conditions.
引用
收藏
页码:335 / 338
页数:4
相关论文
共 18 条
[1]   ROCURONIUM (ORG-9426) FOR CESAREAN-SECTION [J].
ABOULEISH, E ;
ABBOUD, T ;
LECHEVALIER, T ;
ZHU, J ;
CHALIAN, A ;
ALFORD, K .
BRITISH JOURNAL OF ANAESTHESIA, 1994, 73 (03) :336-341
[2]  
AGOSTON S, 1995, EUR J ANAESTH, V12, P31
[3]  
BARTKOWSKI RR, 1993, ANESTH ANALG, V77, P574
[4]  
Belmont M.R., 1995, CURR OPIN ANAESTH, V8, P362
[5]   COMPARISON OF INTUBATING CONDITIONS AFTER ADMINISTRATION OF ORG 9426 (ROCURONIUM) AND SUXAMETHONIUM [J].
COOPER, R ;
MIRAKHUR, RK ;
CLARKE, RSJ ;
BOULES, Z .
BRITISH JOURNAL OF ANAESTHESIA, 1992, 69 (03) :269-273
[6]  
CRUL JF, 1995, EUR J ANAESTH, V12, P111
[7]   INTERACTION OF MAGNESIUM-SULFATE WITH VECURONIUM-INDUCED NEUROMUSCULAR BLOCK [J].
FUCHSBUDER, T ;
WILDERSMITH, OHG ;
BORGEAT, A ;
TASSONYI, E .
BRITISH JOURNAL OF ANAESTHESIA, 1995, 74 (04) :405-409
[8]   ONSET AND DURATION OF NEUROMUSCULAR BLOCKADE FOLLOWING HIGH-DOSE VECURONIUM ADMINISTRATION [J].
GINSBERG, B ;
GLASS, PS ;
QUILL, T ;
SHAFRON, D ;
OSSEY, KD .
ANESTHESIOLOGY, 1989, 71 (02) :201-205
[9]   USE OF SUXAMETHONIUM IN CHILDREN [J].
HOPKINS, PM .
BRITISH JOURNAL OF ANAESTHESIA, 1995, 75 (06) :675-677
[10]   TRACHEAL INTUBATION AFTER INDUCTION OF ANESTHESIA WITH THIOPENTONE OR PROPOFOL WITHOUT MUSCLE-RELAXANTS [J].
HOVORKA, J ;
HONKAVAARA, P ;
KORTTILA, K .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1991, 35 (04) :326-328