Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders

被引：74

作者：

Georgopoulos, Apostolos P. ^{[1
,2
,3
,4
,5
,6
,7
]}

Karageorgiou, Elissaios ^{[1
,2
]}

Leuthold, Arthur C. ^{[1
,2
,7
]}

Lewis, Scott M. ^{[1
,3
,7
]}

Lynch, Joshua K. ^{[1
,2
]}

Alonso, Aurelio A. ^{[1
,8
]}

Aslam, Zaheer ^{[9
]}

Carpenter, Adam F. ^{[3
]}

Georgopoulos, Angeliki ^{[10
,11
]}

Hemmy, Laura S. ^{[12
]}

Koutlas, Ioannis G. ^{[1
,13
]}

Langheim, Frederick J. P. ^{[1
,6
,7
]}

McCarten, J. Riley ^{[3
,12
]}

McPherson, Susan E. ^{[3
,9
]}

Pardo, Jose V. ^{[4
,9
]}

Pardo, Patricia J. ^{[1
,4
,14
]}

Parry, Gareth J. ^{[3
]}

Rottunda, Susan J. ^{[12
]}

Segal, Barbara M. ^{[10
]}

Sponheim, Scott R. ^{[1
,9
,14
]}

Stanwyck, John J. ^{[15
]}

Stephane, Massoud ^{[4
,9
]}

Westermeyer, Joseph J. ^{[4
,9
]}

机构：

[1] Vet Affairs Med Ctr, Brain Sci Ctr, Minneapolis, MN 55417 USA

[2] Univ Minnesota, Sch Med, Dept Neurosci, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Sch Med, Dept Neurol, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA

[5] Univ Minnesota, Ctr Cognit Sci, Minneapolis, MN 55455 USA

[6] Univ Minnesota, MD PhD Program, Minneapolis, MN 55455 USA

[7] Univ Minnesota, Grad Program Neurosci, Minneapolis, MN 55455 USA

[8] Univ Minnesota, Grad Program Oral Biol, Minneapolis, MN 55455 USA

[9] Dept Vet Affairs Med Ctr, Mental Patient Serv Line, Minneapolis, MN 55417 USA

[10] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA

[11] Dept Vet Affairs Med Ctr, Women Vet Comprehens Hlth Ctr, Minneapolis, MN 55417 USA

[12] Dept Vet Affairs Med Ctr, Res & Educ Clin Ctr, Minneapolis, MN 55417 USA

[13] Univ Minnesota, Sch Dent, Dept Diagnost & Biol Sci, Minneapolis, MN 55455 USA

[14] Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA

[15] Dept Vet Affairs Med Ctr, Res Serv, Minneapolis, MN 55417 USA

来源：

JOURNAL OF NEURAL ENGINEERING | 2007年 / 4卷 / 04期

关键词：

D O I：

10.1088/1741-2560/4/4/001

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

We report on a test to assess the dynamic brain function at high temporal resolution using magnetoencephalography (MEG). The essence of the test is the measurement of the dynamic synchronous neural interactions, an essential aspect of the brain function. MEG signals were recorded from 248 axial gradiometers while 142 human subjects fixated a spot of light for 45-60 s. After fitting an autoregressive integrative moving average (ARIMA) model and taking the stationary residuals, all pairwise, zero-lag, partial cross-correlations (PCCij0) and their z-transforms (z(ij)(0)) between i and j sensors were calculated, providing estimates of the strength and sign (positive, negative) of direct synchronous coupling at 1 ms temporal resolution. We found that subsets of z(ij)(0) successfully classified individual subjects to their respective groups (multiple sclerosis, Alzheimer's disease, schizophrenia, Sjogren's syndrome, chronic alcoholism, facial pain, healthy controls) and gave excellent external cross-validation results.

引用

页码：349 / 355

页数：7

共 27 条

[1]

[Anonymous], 1983, Statistical methods

[2]

[Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787

[3]

Resting state oscillatory brain dynamics in Parkinson's disease: An MEG study [J].