Nitric oxide mitigates peroxide-induced iron-signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function?

被引：22

作者：

Kotamraju, S

Tampo, Y

Kalivendi, SV

Joseph, J

Chitambar, CR

Kalyanaraman, B ^{[1
]}

机构：

[1] Med Coll Wisconsin, Dept Biophys, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Free Rad Res Ctr, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Dept Med, Div Neoplast Dis, Milwaukee, WI 53226 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2004年 / 423卷 / 01期

关键词：

D O I：

10.1016/j.abb.2003.12.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In this mini-review, oxidant-induced transferrin receptor-mediated iron-signaling and apoptosis are described in endothelial and neuronal cells exposed to a variety of oxidative stresses. The role of nitric oxide and nitration in the regulation of iron homeostasis and oxidant-induced apoptosis is described. The interrelationship between oxidative stress, iron-signaling, and nitric oxide-dependent proteasomal function provides a rational mechanism that connects both oxidative and nitrative modifications. (C) 2004 Elsevier Inc. All rights reserved.

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页码：74 / 80

页数：7

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