Association of SERPINE2 gene with the risk of chronic obstructive pulmonary disease and spirometric phenotypes in northern Han Chinese population

被引：11

作者：

An, Li ^{[2
]}

Yang, Ting ^{[2
]}

Zhang, Yongbiao ^{[3
]}

Lin, Yingxiang ^{[2
]}

Zhang, Hong ^{[2
]}

Jiao, Xia ^{[2
]}

Hua, Lin ^{[4
]}

Dai, Huaping ^{[2
]}

Wang, Chen ^{[1
,2
]}

机构：

[1] Beijing Hosp, Minist Hlth, Beijing 100020, Peoples R China

[2] Capital Med Univ, Beijing Key Lab Resp & Pulm Circulat Disorders, Beijing Inst Resp Med, Dept Resp & Crit Care Med,Beijing Chao Yang Hosp, Beijing 100020, Peoples R China

[3] Chinese Acad Sci, CAS Key Lab Genome Sci & Informat, Beijing Inst Genom, Beijing 100029, Peoples R China

[4] Capital Med Univ, Inst Biomed Engn, Beijing 100069, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2012年 / 39卷 / 02期

关键词：

Chronic obstructive pulmonary disease; Pulmonary function; SERPINE2; Genetics; Association; PROTEASE-NEXIN; LINKAGE ANALYSIS; EPIDEMIOLOGY; EXPRESSION;

D O I：

10.1007/s11033-011-0877-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Chronic obstructive pulmonary disease (COPD) is a complex human disease influenced by multiple genes and environmental factors. The SERPINE2 gene has recently been demonstrated to be associated with COPD onset in a non-East Asian population. In this study, we genotyped 20 single nucleotide polymorphisms (SNPs) in SERPINE2 from 310 cases and 203 controls, all of which belong to the Han from North China. Genotype frequencies were compared between the cases and the controls and analyzed for statistical significance. Two SNPs (rs729631 and rs975278), which are in strong linkage disequilibrium (LD) and locate in block 1 on the LD map of our samples, showed significant association both with the risk of COPD and decline in baseline lung function after Bonferroni correction (P < 0.05). This study provides further evidences for SERPINE2 gene as a COPD susceptible gene, and block 1 of SERPINE2 appears to be the genetic variant region that affects the Han Chinese.

引用

页码：1427 / 1433

页数：7

共 31 条

[1]

[Anonymous], GLOB STRAT DIAGN MAN

[2]

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