A practical synthesis of L-FMAU from L-arabinose

被引：45

作者：

Du, JF ^{[1
]}

Choi, Y ^{[1
]}

Lee, K ^{[1
]}

Chun, BK ^{[1
]}

Hong, JH ^{[1
]}

Chu, CK ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Ctr Drug Discovery, Athens, GA 30602 USA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 02期

关键词：

D O I：

10.1080/15257779908043066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A practical synthesis of 2'-deoxy-2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil (14, L-FMAU) was developed from L-arabinose. L-Arabinose was converted to L-ribose 5, which was used for the synthesis of bromosugar 12 via 2,3,5-O-tribenzoyl-1-O-acetyl-beta-L-ribofuranose 8, which was subjected to condensation with silylated thymine and the resulting protected L-FMAU 13 was deprotected to afford L-FMAU in 14 steps in 8 % overall yield.

引用

页码：187 / 195

页数：9

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