HIV-1 replication inhibitors of the styrylquinoline class:: incorporation of a masked diketo acid pharmacophore

被引：41

作者：

Zouhiri, F

Desmaële, D

d'Angelo, J

Ourevitch, M

Mouscadet, JF

Leh, H

Le Bret, M

机构：

[1] Fac Pharm Chatenay Malabry, CNRS, Unite Associee, F-92290 Chatenay Malabry, France

[2] Inst Gustave Roussy, CNRS, Unite Associee, F-94805 Villejuif, France

[3] BioAlliance Pharma SA, F-75015 Paris, France

[4] Ecole Normale Super, CNRS, Unite Associee, F-94235 Cachan, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 46期

关键词：

antivirals; enzyme inhibitors; keto acids and derivatives; quinolines; thioacetals;

D O I：

10.1016/S0040-4039(01)01767-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel variant of HIV-1 replication inhibitors of the styrylquinoline class, bearing an alpha -keto acid appendage at C-7, has been synthesized. Though completely inactive in in vitro experiments against HIV-1 integrase, this compound exhibited a significant antiviral activity (IC50 = 10 muM). (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：8189 / 8192

页数：4

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