Thrombus formation in vivo

被引：359

作者：

Furie, B

Furie, BC

机构：

[1] Beth Israel Deaconess Med Ctr, Div Hemostasis & Thrombosis, Vasc Biol Res Ctr, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 12期

关键词：

D O I：

10.1172/JCI26987

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To examine thrombus formation in a living mouse, new technologies involving intravital videomicroscopy have been applied to the analysis of vascular windows to directly visualize arterioles and venules. After vessel wall injury in the microcirculation, thrombus development can be imaged in real time. These systems have been used to explore the role of platelets, blood coagulation proteins, endothelium, and the vessel wall during thrombus formation. The study of biochemistry and cell biology in a living animal offers new understanding of physiology and pathology in complex biologic systems.

引用

页码：3355 / 3362

页数：8

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