NMDA receptor activation limits the number of synaptic connections during hippocampal development

被引：109

作者：

Lüthi, A ^{[1
]}

Schwyzer, L ^{[1
]}

Mateos, JM ^{[1
]}

Gähwiler, BH ^{[1
]}

McKinney, RA ^{[1
]}

机构：

[1] Univ Zurich, Brain Res Inst, CH-8057 Zurich, Switzerland

来源：

NATURE NEUROSCIENCE | 2001年 / 4卷 / 11期

关键词：

D O I：

10.1038/nn744

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Activity-dependent synaptic plasticity triggered by N-methyl-D-aspartate (NMDA) receptor activation is a fundamental property of many glutamatergic synapses and may be critical for the shaping and refinement of the structural and functional properties of neuronal circuits during early postnatal development. Using a combined morphological and electrophysiological approach, we showed that chronic blockade of NMDA receptors in hippocampal slice cultures during the first two weeks of postnatal development leads to a substantial increase in synapse number and results in a more complex dendritic arborization of CA1 pyramidal cells. Thus, the development of excitatory circuitry in the hippocampus is determined by two opposing processes: NMDA receptor-independent synapse formation and NMDA receptor-dependent attenuation of synaptogenesis.

引用

页码：1102 / 1107

页数：6

共 36 条

[1] A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].

BLISS, TVP ;

COLLINGRIDGE, GL .

NATURE, 1993, 361 (6407) :31-39

[2]

CLINE HT, 1999, DENDRITES, P35

[3] Chronic NMDA receptor blockade from birth increases the sprouting capacity of ipsilateral retinocollicular axons without disrupting their early segregation [J].

Colonnese, MT ;

Constantine-Paton, M .

JOURNAL OF NEUROSCIENCE, 2001, 21 (05) :1557-1568

[4] LTP and activity-dependent synaptogenesis: the more alike they are, the more different they become [J].

Constantine-Paton, M ;

Cline, HT .

CURRENT OPINION IN NEUROBIOLOGY, 1998, 8 (01) :139-148

[5] Bidirectional associative plasticity of unitary CA3-CA1 EPSPs in the rat hippocampus in vitro [J].

Debanne, D ;

Gahwiler, BH ;

Thompson, SM .

JOURNAL OF NEUROPHYSIOLOGY, 1997, 77 (05) :2851-2855

[6] Cooperative interactions in the induction of long-term potentiation and depression of synaptic excitation between hippocampal CA3-CA1 cell pairs in vitro [J].

Debanne, D ;

Gahwiler, BH ;

Thompson, SM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (20) :11225-11230

[7] Long-term potentiation and functional synapse induction in developing hippocampus [J].

Durand, GM ;

Kovalchuk, Y ;

Konnerth, A .

NATURE, 1996, 381 (6577) :71-75

[8] Dendritic spine changes associated with hippocampal long-term synaptic plasticity [J].

Engert, F ;

Bonhoeffer, T .

NATURE, 1999, 399 (6731) :66-70

[9] Glutamate receptor blockade at cortical synapses disrupts development of thalamocortical and columnar organization in somatosensory cortex [J].

Fox, K ;

Schlaggar, BL ;

Glazewski, S ;

OLeary, DDM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) :5584-5589

[10] Assembly of new individual excitatory synapses: Time course and temporal order of synaptic molecule recruitment [J].

Friedman, HV ;

Bresler, T ;

Garner, CC ;

Ziv, NE .

NEURON, 2000, 27 (01) :57-69

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