Slow injection of prostaglandin E(1) decreases associated penile pain

Objectives, A randomized, double-blind study to determine whether speed of intracavernous injection of prostaglandin E(1) (PGE(1)) is associated with pain. Methods. On two separate occasions, using two different speeds of injection (5 versus 60 seconds), 11 subjects received the same dose of PGE(1) that they used at home, The presence, duration, and intensity of pain were recorded. Results, We found that fast penile injection of PGE(1) was associated with a greater intensity of pain (P = 0.04). Conclusions. Slow injection of PGE(1) is less often associated with penile pain, the most common adverse effect of this treatment.